Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium

Sang Jip Nam, Christopher A. Kauffman, Paul R. Jensen, Curtis E. Moore, Arnold L. Rheingold, William Fenical

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

(Chemical Equation Presented) Chemical investigation of a marine actinomycete within the family Streptomycetaceae (our strain CNQ-149) has led to the isolation of the unprecedented alkaloids, actinobenzoquinoline (1) and actinophenanthrolines A-C (2-4). The chemical structures of 1-4 were assigned by interpretation of NMR spectroscopic data, and their absolute configurations were assigned by X-ray analysis. Actinobenzoquinoline possesses a 5-methyloxazolidin-4-one moiety and a dihydrobenzo[h]quinoline core structure, while actinophenanthrolines A-C are composed of hydroxypropanamide-substituted 1,7-phenanthroline core skeletons.

Original languageEnglish
Pages (from-to)3240-3243
Number of pages4
JournalOrganic Letters
Volume17
Issue number13
DOIs
StatePublished - 2 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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