Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Hiyoung Kim; Inho Yang; Shin Young Ryu; Dong Hwan Won; Awadut G. Giri; Weihong Wang; Hyukjae Choi; Jungwook Chin; Dongyup Hahn; Eunhee Kim; Chulkyeong Han; Jihye Lee; Sang Jip Nam; Won Kyung Ho; Heonjoong Kang

doi:10.1021/np5007586

Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Hiyoung Kim
, Inho Yang
, Shin Young Ryu
, Dong Hwan Won
, Awadut G. Giri
, Weihong Wang
, Hyukjae Choi
, Jungwook Chin
, Dongyup Hahn
, Eunhee Kim
, Chulkyeong Han
, Jihye Lee
, Sang Jip Nam
, Won Kyung Ho
, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K⁺ currents of the insulin secreting cell line INS-1 with IC₅₀ values of 0.59 and 1.0 μM, respectively.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	3
DOIs	https://doi.org/10.1021/np5007586
State	Published - 27 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.

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title = "Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015",

abstract = "Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.",

author = "Hiyoung Kim and Inho Yang and Ryu, \{Shin Young\} and Won, \{Dong Hwan\} and Giri, \{Awadut G.\} and Weihong Wang and Hyukjae Choi and Jungwook Chin and Dongyup Hahn and Eunhee Kim and Chulkyeong Han and Jihye Lee and Nam, \{Sang Jip\} and Ho, \{Won Kyung\} and Heonjoong Kang",

note = "Publisher Copyright: {\textcopyright} 2015 The American Chemical Society and American Society of Pharmacognosy.",

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month = mar,

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doi = "10.1021/np5007586",

language = "English",

volume = "78",

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TY - JOUR

T1 - Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

AU - Kim, Hiyoung

AU - Yang, Inho

AU - Ryu, Shin Young

AU - Won, Dong Hwan

AU - Giri, Awadut G.

AU - Wang, Weihong

AU - Choi, Hyukjae

AU - Chin, Jungwook

AU - Hahn, Dongyup

AU - Kim, Eunhee

AU - Han, Chulkyeong

AU - Lee, Jihye

AU - Nam, Sang Jip

AU - Ho, Won Kyung

AU - Kang, Heonjoong

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

AB - Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

UR - https://www.scopus.com/pages/publications/84925956363

U2 - 10.1021/np5007586

DO - 10.1021/np5007586

M3 - Article

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AN - SCOPUS:84925956363

SN - 0163-3864

VL - 78

SP - 363

EP - 367

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Abstract

Bibliographical note

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