Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Hiyoung Kim; Inho Yang; Shin Young Ryu; Dong Hwan Won; Awadut G. Giri; Weihong Wang; Hyukjae Choi; Jungwook Chin; Dongyup Hahn; Eunhee Kim; Chulkyeong Han; Jihye Lee; Sang Jip Nam; Won Kyung Ho; Heonjoong Kang

doi:10.1021/np5007586

Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Hiyoung Kim, Inho Yang, Shin Young Ryu, Dong Hwan Won, Awadut G. Giri, Weihong Wang, Hyukjae Choi, Jungwook Chin, Dongyup Hahn, Eunhee Kim, Chulkyeong Han, Jihye Lee, Sang Jip Nam, Won Kyung Ho, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K⁺ currents of the insulin secreting cell line INS-1 with IC₅₀ values of 0.59 and 1.0 μM, respectively.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	3
DOIs	https://doi.org/10.1021/np5007586
State	Published - 27 Mar 2015

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© 2015 The American Chemical Society and American Society of Pharmacognosy.

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title = "Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015",

abstract = "Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.",

author = "Hiyoung Kim and Inho Yang and Ryu, {Shin Young} and Won, {Dong Hwan} and Giri, {Awadut G.} and Weihong Wang and Hyukjae Choi and Jungwook Chin and Dongyup Hahn and Eunhee Kim and Chulkyeong Han and Jihye Lee and Nam, {Sang Jip} and Ho, {Won Kyung} and Heonjoong Kang",

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doi = "10.1021/np5007586",

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T1 - Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

AU - Kim, Hiyoung

AU - Yang, Inho

AU - Ryu, Shin Young

AU - Won, Dong Hwan

AU - Giri, Awadut G.

AU - Wang, Weihong

AU - Choi, Hyukjae

AU - Chin, Jungwook

AU - Hahn, Dongyup

AU - Kim, Eunhee

AU - Han, Chulkyeong

AU - Lee, Jihye

AU - Nam, Sang Jip

AU - Ho, Won Kyung

AU - Kang, Heonjoong

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

AB - Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

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ER -

Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Abstract

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