Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity

Jeong Tae Yeon, Hiyoung Kim, Kwang Jin Kim, Jihye Lee, Dong Hwan Won, Sang Jip Nam, Seong Hwan Kim, Heonjoong Kang, Young Jin Son

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP+-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.

Original languageEnglish
Pages (from-to)1730-1736
Number of pages7
JournalJournal of Natural Products
Volume79
Issue number7
DOIs
StatePublished - 22 Jul 2016

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