Abstract
A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP+-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.
| Original language | English |
|---|---|
| Pages (from-to) | 1730-1736 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 79 |
| Issue number | 7 |
| DOIs | |
| State | Published - 22 Jul 2016 |
Bibliographical note
Funding Information:This research was supported by the National Research Foundation of Korea (NRF) grants funded by the Ministry of Science, ICT and Future Planning (MSIP) (2015R1A4A1041219 and 2015M1A5A1037572), and the Marine Biotechnology Program, Ministry of Oceans and Fisheries, Korea.
Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.