@article{8fc558cfa26f4dd7a844fc036cc9c7dc,
title = "Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm",
abstract = "Combating biofilm infections remains a challenge due to the shield and acidic conditions. Herein, an acid-responsive nanoporphyrin (PN3-NP) based on the self-assembly of a water-soluble porphyrin derivative (PN3) is constructed. Additional kinetic control sites formed by the conjugation of the spermine molecules to a porphyrin macrocycle make PN3 self-assemble into stable nanoparticles (PN3-NP) in the physiological environment. Noteworthily, near-infrared (NIR) fluorescence monitoring and synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) effects of PN3-NP can be triggered by the acidity in biofilms, accompanied by intelligent transformation into dot-like nanospheres. Thus, damage to normal tissue is effectively avoided and accurate diagnosis and treatment of biofilms is achieved successfully. The good results of fluorescence imaging-guided photo-ablation of antibiotic-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) biofilms verify that PN3-NP is a promising alternative to antibiotics. Meanwhile, this strategy also opens new horizons to engineer smart nano-photosensitizer for accurate diagnosis and treatment of biofilms.",
keywords = "MRSA biofilms, NIR fluorescence, acid-responsive nanoporphyrin, phototherapy, structural evolution",
author = "Mengyao Yang and Zulal {\"O}zdemir and Heejeong Kim and Sanghee Nah and Erik Andris and Xingshu Li and Zden{\v e}k Wimmer and Juyoung Yoon",
note = "Funding Information: M.Y. and Z.{\"O}. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (Grant No. 22078066, X.L.), and by MPO, grants No. FV10599 and FV30300 (Z.W.), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1A6A1A10039823, 2022R1A2C3005420, J.Y.), and the China Scholarship Council (CSC, No. 201904910820, M.Y.). Z.{\"O}. thanks the Czech Academy of Sciences (Grant No. VAJVA‐19‐48) and University of Chemistry and Technology Prague, MOBI traineeship Programme 2019/2020 for support of her visit to the EWHA Womans University. The authors thank Dr. David {\v S}aman for measuring NMR spectra of studied compound. E.A. acknowledges the European Regional Development Fund OP RDE (project ChemBioDrug no. CZ.02.1.01/0.0/0.0/16_019/0000729) for support and computational resources. His work was supported by the Ministry of Education, Youth and Sports of the Czech Republic through the e‐INFRA CZ (ID: 90140). Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = jul,
doi = "10.1002/adhm.202200529",
language = "English",
volume = "11",
journal = "Advanced Healthcare Materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "14",
}