To improve the reactivity of Grubbs catalyst, novel ligands were designed and synthesized which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were treated with a range of acids and the acid salt forms were used as catalysts for ring-closing metathesis (RCM) reactions. As a result, reactions employing the acid-modified catalysts showed considerable reactivity enhancement in RCM.
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Generous financial support from the Korea Research Fund ( 2006-312-C00229 ) is gratefully acknowledged.