Accuracy of volume measurement using 3D ultrasound and development of CT-3D US image fusion algorithm for prostate cancer radiotherapy

Jihye Baek, Jangyoung Huh, Myungsoo Kim, So Hyun An, Yoonjin Oh, Dongyoung Kim, Kwangzoo Chung, Sungho Cho, Rena Lee

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To evaluate the accuracy of measuring volumes using three-dimensional ultrasound (3D US), and to verify the feasibility of the replacement of CT-MR fusion images with CT-3D US in radiotherapy treatment planning. Methods: Phantoms, consisting of water, contrast agent, and agarose, were manufactured. The volume was measured using 3D US, CT, and MR devices. A CT-3D US and MR-3D US image fusion software was developed using the Insight Toolkit library in order to acquire three-dimensional fusion images. The quality of the image fusion was evaluated using metric value and fusion images. Results: Volume measurement, using 3D US, shows a 2.8 ± 1.5% error, 4.4 ± 3.0% error for CT, and 3.1 ± 2.0% error for MR. The results imply that volume measurement using the 3D US devices has a similar accuracy level to that of CT and MR. Three-dimensional image fusion of CT-3D US and MR-3D US was successfully performed using phantom images. Moreover, MR-3D US image fusion was performed using human bladder images. Conclusions: 3D US could be used in the volume measurement of human bladders and prostates. CT-3D US image fusion could be used in monitoring the target position in each fraction of external beam radiation therapy. Moreover, the feasibility of replacing the CT-MR image fusion to the CT-3D US in radiotherapy treatment planning was verified.

Original languageEnglish
Article number021704
JournalMedical Physics
Issue number2
StatePublished - Feb 2013

Bibliographical note

Funding Information:
This research was supported in part by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2009-0085999) and in part by the Ministry of Knowledge Economy (Grant No. 10035495).


  • 3D US volume measurement
  • CT-3D US image fusion
  • prostate cancer radiotherapy


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