Accuracy assessment of five equations used for estimating the glomerular filtration rate in Korean adults

Tae Dong Jeong, Eun Jung Cho, Woochang Lee, Sail Chun, Ki Sook Hong, Won Ki Min

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (EGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund-Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population. Methods: A total of 1, 312 patients, aged 20 yr and above who underwent 51Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (EGFR-mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four EGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose EGFR was within±30% of the mGFR. Results: The mean bias (mL·min-1·1.73 m-2) of the five EGFR equation was as follows: CKD-EPIcr, -0.6; Asian CKD-EPI, 2.7; revised LM, -6.5; FAS, -2.5; and Korean FAS, -0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P<0.001). The RMSE values were as follows: CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation: CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%. Conclusions: The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population.

Original languageEnglish
Pages (from-to)371-380
Number of pages10
JournalAnnals of Laboratory Medicine
Volume37
Issue number5
DOIs
StatePublished - 2017

Keywords

  • Accuracy
  • Comparison
  • Creatinine
  • Equation
  • Glomerular filtration rate

Fingerprint

Dive into the research topics of 'Accuracy assessment of five equations used for estimating the glomerular filtration rate in Korean adults'. Together they form a unique fingerprint.

Cite this