Accelerated Partial Breast Irradiation: Florence Phase 3 Trial Experience and Future Perspectives

Icro Meattini, Kyubo Kim, Lorenzo Livi

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1 Scopus citations

Abstract

Accelerated partial breast irradiation Florence phase 3 trial is a single-center study comparing intensity-modulated based accelerated partial breast irradiation (PBI, 30 Gy in 5 fractions) and whole breast irradiation (50 Gy in 25 fractions) followed by a tumor bed boost (10 Gy in 5 fractions). This easy-to-deliver PBI approach showed excellent long-term disease control with favorable safety and cosmetic outcome profiles. A plateau has been probably reached concerning the reduction of the number of fractions in the postoperative PBI setting. A 5-fraction schedule is the standard regimen and probably the appropriate compromise in terms of efficacy, safety, and quality of life, also considering the negative results of most intraoperative single-fraction PBI trials. A new frontier is now open on the potential benefit of preoperative PBI delivery, although concerns remain on the optimal dose, fractionation, and technique. Hereby we report the accelerated PBI Florence phase 3 trial experience and future perspectives.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume46
Issue number1
DOIs
StatePublished - 1 Jan 2023

Bibliographical note

Publisher Copyright:
© 2023 Authors. All rights reserved.

Keywords

  • Florence trial
  • breast cancer
  • intensity-modulated radiotherapy
  • partial breast irradiation
  • phase 3

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