Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression

Yeung Bae Jin, Seo Hyun Choi, Jae Seon Lee, Jae Kyung Kim, Ju Woon Lee, Seung Cheol Hong, Sung Ho Myung, Yun Sil Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The principal objective of this study was to assess the DNA damage in a normal cell line system after exposure to 60 Hz of extremely low frequency magnetic field (ELF-MF) and particularly in combination with various external factors, via comet assays. NIH3T3 mouse fibroblast cells, WI-38 human lung fibroblast cells, L132 human lung epithelial cells, and MCF10A human mammary gland epithelial cells were exposed for 4 or 16 h to a 60-Hz, 1 mT uniform magnetic field in the presence or absence of ionizing radiation (IR, 1 Gy), H2O2 (50 μM), or c-Myc oncogenic activation. The results obtained showed no significant differences between the cells exposed to ELF-MF alone and the unexposed cells. Moreover, no synergistic or additive effects were observed after 4 or 16 h of pre-exposure to 1 mT ELF-MF or simultaneous exposure to ELF-MF combined with IR, H2O2, or c-Myc activation.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalRadiation and Environmental Biophysics
Volume53
Issue number1
DOIs
StatePublished - Mar 2014

Keywords

  • Combined treatment
  • Comet olive tail moment for DNA damage
  • Extremely low frequency

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