Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease

Won Dong Kim; Woo Sung Kim; Younsuck Koh; Sang Do Lee; Chae Man Lim; Tae Sun Shim; Dong Soon Kim; Young Joo Cho

doi:10.1109/KORUS.2002.1028073

Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease

Won Dong Kim, Woo Sung Kim, Younsuck Koh, Sang Do Lee, Chae Man Lim, Tae Sun Shim, Dong Soon Kim, Young Joo Cho

Department of Internal Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Purpose: Smoking may induce changes in T lymphocyte cell subsets in peripheral blood. Abnormality of T lymphocyte cell subsets in peripheral blood and in bronchoalveolar-lavage fluid, and increased CD8+ T lymphocytes in the airways have been reported in patients with COPD. These findings suggest that T lymphocyte abnormalities might play a role in the pathogenesis of airflow limitation in smokers. To investigate this hypothesis this study was performed. Methods: Peripheral blood T lymphocyte cell subsets were measured by flow cytometry using specific monoclonal antibodies in 20 healthy nonsmokers, 20 healthy smokers, and 20 smokers with stable COPD. No significant differences in the peripheral blood T lymphocyte cell subsets were observed between the three groups. Because a previous study had shown peripheral blood T lymphocyte abnormalities in the subgroup of nonsmoking COPD subjects, we wanted to investigate what factors determine the subgroup of COPD with abnormal T lymphocyte cell subsets. We tried to measure the relationship between T lymphocyte cell subsets and physiologic indices of pulmonary function tests in smokers with COPD. The proportion of CD8+ T lymphocytes significantly correlated with DLco (p= 0.012) and DLco/VA (p=0.002), and CD4+/CD8+ ratio correlated with DLco/VA (p=0.01). Therefore, we attempted to divide the smokers with COPD into two subgroups on the basis of DLco/VA. Ten patients with low DLco/VA (DLco/VA<80 per cent predicted; COPD/low DLco/VA) and 10 patients with normal DLco/VA (DLco/VA≥80 per cent, COPD/normal DLco/VA) were subclassified. Results: The COPD/normal DLco/VA subgroup had a significantly higher proportion of CD8+ T lymphocytes (p<0.5) and lower CD4+/CD8+ ratio (p<0.05) than the healthy smokers or COPD/low DLco/VA subgroup. Moreover,. FEV₁/FVC significantly correlated with the CD4+/CD8+ ratio only in the COPD/normal DLco/VA subgroup (p=0.044). Conclusion: These findings suggest that T lymphocyte abnormalities might be involved in the pathogenesis of airflow limitation in a subgroup of COPE patients, presumably with small airways disease, but not in all COPD.

Original language	English
Title of host publication	Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	494-497
Number of pages	4
ISBN (Electronic)	0780374274, 9780780374270
DOIs	https://doi.org/10.1109/KORUS.2002.1028073
State	Published - 2002
Event	6th Russian-Korean International Symposium on Science and Technology, KORUS 2002 - Novosibirsk, Russian Federation Duration: 24 Jun 2002 → 30 Jun 2002

Publication series

Name	Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002

Conference

Conference	6th Russian-Korean International Symposium on Science and Technology, KORUS 2002
Country/Territory	Russian Federation
City	Novosibirsk
Period	24/06/02 → 30/06/02

Bibliographical note

Publisher Copyright:
© 2002 IEEE.

Keywords

CD8+ T lymphocyte
Chronic obstructive pulmonary disease (COPD)
Diffusing capacity
T lymphocyte cell subsets

Access to Document

10.1109/KORUS.2002.1028073

Cite this

Kim, W. D., Kim, W. S., Koh, Y., Lee, S. D., Lim, C. M., Shim, T. S., Kim, D. S., & Cho, Y. J. (2002). Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease. In Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002 (pp. 494-497). Article 1028073 (Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/KORUS.2002.1028073

Kim, Won Dong ; Kim, Woo Sung ; Koh, Younsuck et al. / Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease. Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002. Institute of Electrical and Electronics Engineers Inc., 2002. pp. 494-497 (Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002).

@inproceedings{3af7917714ea4f4aadc29490f483572e,

title = "Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease",

abstract = "Purpose: Smoking may induce changes in T lymphocyte cell subsets in peripheral blood. Abnormality of T lymphocyte cell subsets in peripheral blood and in bronchoalveolar-lavage fluid, and increased CD8+ T lymphocytes in the airways have been reported in patients with COPD. These findings suggest that T lymphocyte abnormalities might play a role in the pathogenesis of airflow limitation in smokers. To investigate this hypothesis this study was performed. Methods: Peripheral blood T lymphocyte cell subsets were measured by flow cytometry using specific monoclonal antibodies in 20 healthy nonsmokers, 20 healthy smokers, and 20 smokers with stable COPD. No significant differences in the peripheral blood T lymphocyte cell subsets were observed between the three groups. Because a previous study had shown peripheral blood T lymphocyte abnormalities in the subgroup of nonsmoking COPD subjects, we wanted to investigate what factors determine the subgroup of COPD with abnormal T lymphocyte cell subsets. We tried to measure the relationship between T lymphocyte cell subsets and physiologic indices of pulmonary function tests in smokers with COPD. The proportion of CD8+ T lymphocytes significantly correlated with DLco (p= 0.012) and DLco/VA (p=0.002), and CD4+/CD8+ ratio correlated with DLco/VA (p=0.01). Therefore, we attempted to divide the smokers with COPD into two subgroups on the basis of DLco/VA. Ten patients with low DLco/VA (DLco/VA<80 per cent predicted; COPD/low DLco/VA) and 10 patients with normal DLco/VA (DLco/VA≥80 per cent, COPD/normal DLco/VA) were subclassified. Results: The COPD/normal DLco/VA subgroup had a significantly higher proportion of CD8+ T lymphocytes (p<0.5) and lower CD4+/CD8+ ratio (p<0.05) than the healthy smokers or COPD/low DLco/VA subgroup. Moreover,. FEV1/FVC significantly correlated with the CD4+/CD8+ ratio only in the COPD/normal DLco/VA subgroup (p=0.044). Conclusion: These findings suggest that T lymphocyte abnormalities might be involved in the pathogenesis of airflow limitation in a subgroup of COPE patients, presumably with small airways disease, but not in all COPD.",

keywords = "CD8+ T lymphocyte, Chronic obstructive pulmonary disease (COPD), Diffusing capacity, T lymphocyte cell subsets",

author = "Kim, {Won Dong} and Kim, {Woo Sung} and Younsuck Koh and Lee, {Sang Do} and Lim, {Chae Man} and Shim, {Tae Sun} and Kim, {Dong Soon} and Cho, {Young Joo}",

note = "Publisher Copyright: {\textcopyright} 2002 IEEE.; 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002 ; Conference date: 24-06-2002 Through 30-06-2002",

year = "2002",

doi = "10.1109/KORUS.2002.1028073",

language = "English",

series = "Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "494--497",

booktitle = "Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002",

}

Kim, WD, Kim, WS, Koh, Y, Lee, SD, Lim, CM, Shim, TS, Kim, DS & Cho, YJ 2002, Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease. in Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002., 1028073, Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002, Institute of Electrical and Electronics Engineers Inc., pp. 494-497, 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002, Novosibirsk, Russian Federation, 24/06/02. https://doi.org/10.1109/KORUS.2002.1028073

Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease. / Kim, Won Dong; Kim, Woo Sung; Koh, Younsuck et al.
Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002. Institute of Electrical and Electronics Engineers Inc., 2002. p. 494-497 1028073 (Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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AU - Kim, Won Dong

AU - Kim, Woo Sung

AU - Koh, Younsuck

AU - Lee, Sang Do

AU - Lim, Chae Man

AU - Shim, Tae Sun

AU - Kim, Dong Soon

AU - Cho, Young Joo

PY - 2002

Y1 - 2002

N2 - Purpose: Smoking may induce changes in T lymphocyte cell subsets in peripheral blood. Abnormality of T lymphocyte cell subsets in peripheral blood and in bronchoalveolar-lavage fluid, and increased CD8+ T lymphocytes in the airways have been reported in patients with COPD. These findings suggest that T lymphocyte abnormalities might play a role in the pathogenesis of airflow limitation in smokers. To investigate this hypothesis this study was performed. Methods: Peripheral blood T lymphocyte cell subsets were measured by flow cytometry using specific monoclonal antibodies in 20 healthy nonsmokers, 20 healthy smokers, and 20 smokers with stable COPD. No significant differences in the peripheral blood T lymphocyte cell subsets were observed between the three groups. Because a previous study had shown peripheral blood T lymphocyte abnormalities in the subgroup of nonsmoking COPD subjects, we wanted to investigate what factors determine the subgroup of COPD with abnormal T lymphocyte cell subsets. We tried to measure the relationship between T lymphocyte cell subsets and physiologic indices of pulmonary function tests in smokers with COPD. The proportion of CD8+ T lymphocytes significantly correlated with DLco (p= 0.012) and DLco/VA (p=0.002), and CD4+/CD8+ ratio correlated with DLco/VA (p=0.01). Therefore, we attempted to divide the smokers with COPD into two subgroups on the basis of DLco/VA. Ten patients with low DLco/VA (DLco/VA<80 per cent predicted; COPD/low DLco/VA) and 10 patients with normal DLco/VA (DLco/VA≥80 per cent, COPD/normal DLco/VA) were subclassified. Results: The COPD/normal DLco/VA subgroup had a significantly higher proportion of CD8+ T lymphocytes (p<0.5) and lower CD4+/CD8+ ratio (p<0.05) than the healthy smokers or COPD/low DLco/VA subgroup. Moreover,. FEV1/FVC significantly correlated with the CD4+/CD8+ ratio only in the COPD/normal DLco/VA subgroup (p=0.044). Conclusion: These findings suggest that T lymphocyte abnormalities might be involved in the pathogenesis of airflow limitation in a subgroup of COPE patients, presumably with small airways disease, but not in all COPD.

AB - Purpose: Smoking may induce changes in T lymphocyte cell subsets in peripheral blood. Abnormality of T lymphocyte cell subsets in peripheral blood and in bronchoalveolar-lavage fluid, and increased CD8+ T lymphocytes in the airways have been reported in patients with COPD. These findings suggest that T lymphocyte abnormalities might play a role in the pathogenesis of airflow limitation in smokers. To investigate this hypothesis this study was performed. Methods: Peripheral blood T lymphocyte cell subsets were measured by flow cytometry using specific monoclonal antibodies in 20 healthy nonsmokers, 20 healthy smokers, and 20 smokers with stable COPD. No significant differences in the peripheral blood T lymphocyte cell subsets were observed between the three groups. Because a previous study had shown peripheral blood T lymphocyte abnormalities in the subgroup of nonsmoking COPD subjects, we wanted to investigate what factors determine the subgroup of COPD with abnormal T lymphocyte cell subsets. We tried to measure the relationship between T lymphocyte cell subsets and physiologic indices of pulmonary function tests in smokers with COPD. The proportion of CD8+ T lymphocytes significantly correlated with DLco (p= 0.012) and DLco/VA (p=0.002), and CD4+/CD8+ ratio correlated with DLco/VA (p=0.01). Therefore, we attempted to divide the smokers with COPD into two subgroups on the basis of DLco/VA. Ten patients with low DLco/VA (DLco/VA<80 per cent predicted; COPD/low DLco/VA) and 10 patients with normal DLco/VA (DLco/VA≥80 per cent, COPD/normal DLco/VA) were subclassified. Results: The COPD/normal DLco/VA subgroup had a significantly higher proportion of CD8+ T lymphocytes (p<0.5) and lower CD4+/CD8+ ratio (p<0.05) than the healthy smokers or COPD/low DLco/VA subgroup. Moreover,. FEV1/FVC significantly correlated with the CD4+/CD8+ ratio only in the COPD/normal DLco/VA subgroup (p=0.044). Conclusion: These findings suggest that T lymphocyte abnormalities might be involved in the pathogenesis of airflow limitation in a subgroup of COPE patients, presumably with small airways disease, but not in all COPD.

KW - CD8+ T lymphocyte

KW - Chronic obstructive pulmonary disease (COPD)

KW - Diffusing capacity

KW - T lymphocyte cell subsets

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DO - 10.1109/KORUS.2002.1028073

M3 - Conference contribution

AN - SCOPUS:84961595324

T3 - Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002

SP - 494

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BT - Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002

Y2 - 24 June 2002 through 30 June 2002

ER -

Kim WD, Kim WS, Koh Y, Lee SD, Lim CM, Shim TS et al. Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease. In Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002. Institute of Electrical and Electronics Engineers Inc. 2002. p. 494-497. 1028073. (Proceedings - 6th Russian-Korean International Symposium on Science and Technology, KORUS 2002). doi: 10.1109/KORUS.2002.1028073

Abnormal peripheral blood T lymphocyte cell subsets in a subgroup of patients with chronic obstructive pulmonary disease

Abstract

Publication series

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Keywords

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