Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Hila Zigdon; Aviram Kogot-Levin; Joo Won Park; Ruth Goldschmidt; Samuel Kelly; Alfred H. Merrill; Avigdor Scherz; Yael Pewzner-Jung; Ann Saada; Anthony H. Futerman

doi:10.1074/jbc.M112.402719

Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Hila Zigdon, Aviram Kogot-Levin, Joo Won Park, Ruth Goldschmidt, Samuel Kelly, Alfred H. Merrill, Avigdor Scherz, Yael Pewzner-Jung, Ann Saada, Anthony H. Futerman

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

Original language	English
Pages (from-to)	4947-4956
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.402719
State	Published - 15 Feb 2013

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title = "Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain",

abstract = "Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.",

author = "Hila Zigdon and Aviram Kogot-Levin and Park, {Joo Won} and Ruth Goldschmidt and Samuel Kelly and Merrill, {Alfred H.} and Avigdor Scherz and Yael Pewzner-Jung and Ann Saada and Futerman, {Anthony H.}",

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AU - Zigdon, Hila

AU - Kogot-Levin, Aviram

AU - Park, Joo Won

AU - Goldschmidt, Ruth

AU - Kelly, Samuel

AU - Merrill, Alfred H.

AU - Scherz, Avigdor

AU - Pewzner-Jung, Yael

AU - Saada, Ann

AU - Futerman, Anthony H.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

AB - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

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JO - Journal of Biological Chemistry

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Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

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