Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia

Geon Ha Kim; Bori R. Kim; Min Young Chun; Kee Duk Park; Soo Mee Lim; Jee Hyang Jeong

doi:10.1038/s41598-021-97842-y

Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia

Geon Ha Kim, Bori R. Kim, Min Young Chun, Kee Duk Park, Soo Mee Lim, Jee Hyang Jeong

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insight useful for the pathophysiology of TGA. Fifty TGA patients underwent the resting state functional magnetic resonance imaging (rsfMRI) within 24 h, at 72 h, and 3 months after TGA onset. Twenty-five age, gender matched controls also underwent rsfMRI. Within 24 h of TGA onset, TGA patients showed greater functional connectivity in the SN and lower functional connectivity in the DMN, while relatively preserved functional connectivity was observed in the CEN. Interestingly, TGA patients continued to show decreased connectivity in the DMN, while no alterations were shown in the SN 72 h after illness onset. Three months after TGA onset, alterations of functional connectivity in the SN or the DMN were normalized. Our findings suggest that TGA is associated with transient greater functional connectivity in the SN and lower connectivity in the DMN.

Original language	English
Article number	20598
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-97842-y
State	Published - Dec 2021

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT for convergent research in a development program for convergence R&D of science and technology and liberal arts (NRF-2020M3C1B6112160), an Original Technology Research Program for Brain Science through the NRF funded by the Ministry of Science and ICT (NRF-2018M3C7A1057137), Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2020R1I1A1A01072283), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of Korea (HI18C0460, HU20C0271 and HU21C0016), and an Ewha alumni medical research grant.

Publisher Copyright:
© 2021, The Author(s).

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title = "Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia",

abstract = "Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insight useful for the pathophysiology of TGA. Fifty TGA patients underwent the resting state functional magnetic resonance imaging (rsfMRI) within 24 h, at 72 h, and 3 months after TGA onset. Twenty-five age, gender matched controls also underwent rsfMRI. Within 24 h of TGA onset, TGA patients showed greater functional connectivity in the SN and lower functional connectivity in the DMN, while relatively preserved functional connectivity was observed in the CEN. Interestingly, TGA patients continued to show decreased connectivity in the DMN, while no alterations were shown in the SN 72 h after illness onset. Three months after TGA onset, alterations of functional connectivity in the SN or the DMN were normalized. Our findings suggest that TGA is associated with transient greater functional connectivity in the SN and lower connectivity in the DMN.",

author = "Kim, {Geon Ha} and Kim, {Bori R.} and Chun, {Min Young} and Park, {Kee Duk} and Lim, {Soo Mee} and Jeong, {Jee Hyang}",

note = "Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT for convergent research in a development program for convergence R&D of science and technology and liberal arts (NRF-2020M3C1B6112160), an Original Technology Research Program for Brain Science through the NRF funded by the Ministry of Science and ICT (NRF-2018M3C7A1057137), Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2020R1I1A1A01072283), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of Korea (HI18C0460, HU20C0271 and HU21C0016), and an Ewha alumni medical research grant. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Lim, Soo Mee

AU - Jeong, Jee Hyang

N1 - Funding Information: This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT for convergent research in a development program for convergence R&D of science and technology and liberal arts (NRF-2020M3C1B6112160), an Original Technology Research Program for Brain Science through the NRF funded by the Ministry of Science and ICT (NRF-2018M3C7A1057137), Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2020R1I1A1A01072283), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare of Korea (HI18C0460, HU20C0271 and HU21C0016), and an Ewha alumni medical research grant. Publisher Copyright: © 2021, The Author(s).

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N2 - Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insight useful for the pathophysiology of TGA. Fifty TGA patients underwent the resting state functional magnetic resonance imaging (rsfMRI) within 24 h, at 72 h, and 3 months after TGA onset. Twenty-five age, gender matched controls also underwent rsfMRI. Within 24 h of TGA onset, TGA patients showed greater functional connectivity in the SN and lower functional connectivity in the DMN, while relatively preserved functional connectivity was observed in the CEN. Interestingly, TGA patients continued to show decreased connectivity in the DMN, while no alterations were shown in the SN 72 h after illness onset. Three months after TGA onset, alterations of functional connectivity in the SN or the DMN were normalized. Our findings suggest that TGA is associated with transient greater functional connectivity in the SN and lower connectivity in the DMN.

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Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia

Abstract

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