TY - JOUR
T1 - Abdominal pain accompanied by weight loss may increase the diagnostic yield of capsule endoscopy
T2 - A Korean multicenter study
AU - Shim, Ki Nam
AU - Kim, Yong Sik
AU - Kim, Kyung Jo
AU - Kim, Young Ho
AU - Kim, Tae Il
AU - Do, Jae Hyuk
AU - Ryu, Ji Kon
AU - Moon, Jeong Seop
AU - Park, Soo Heon
AU - Hee Park, Cheol
AU - Lee, Kee Myung
AU - Lee, In Seok
AU - Chun, Hoon Jai
AU - Jung, In Seop
AU - Choi, Myung Gyu
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Objective. Capsule endoscopy (CE) is approved for the evaluation of obscure gastrointestinal (GI) bleeding and its use has increased in the assessment of patients with various small-bowel disorders. The yield of CE for indications of disorders other than GI bleeding is not yet well described. The aim of the present study was to determine in which subgroup of patients with unexplained abdominal pain, CE would be a helpful evaluation tool. Material and methods . The results of CE in 110 patients (70 M, 40 F, mean age 50.8±14.1 years) with unexplained abdominal pain from 12 tertiary referral centers between September 2002 and September 2004 were retrospectively analyzed. Results. The visualization of the small bowel to the cecum was successfully carried out in 69.1% of the patients. Nineteen out of the 110 cases revealed positive findings that explained the symptoms of the patient (diagnostic yield = 17.3%). Diagnosis included small-bowel stricture (5), Crohn's disease (3), small-bowel tumor (2), radiation-induced enteritis (1), NSAID-induced enteropathy (1), ischemic ileitis (1), diffuse lymphangiectasia (1), and significant erosion or ulceration (5). By univariate logistic regression analysis, the positive findings of CE were significantly associated with weight loss (odds ratio (OR), 11.9; 95% CI [2.0, 70.6]), elevated erythrocyte sedimentation rate (ESR)(>20 mm/h) (OR, 11.5; 95% CI (1.9, 69.5)), elevated C-reactive protein (CRP) (≥0.4 mg/dL) (OR, 5.0; 95% CI (1.6, 15.9)), and hypoalbuminemia (albumin <3 g/dL) (OR, 23.1; 95% CI (2.4,223.1)). Using a multivariate analysis, weight loss was found to be a significant risk factor for positive findings of CE (OR, 18.6; 95% CI (1.6, 222.4), p = 0.02). Conclusions. The results of this study suggest that CE can be helpful in patients suffering from abdominal pain that cannot be explained by established examinations, if the pain is accompanied by weight loss.
AB - Objective. Capsule endoscopy (CE) is approved for the evaluation of obscure gastrointestinal (GI) bleeding and its use has increased in the assessment of patients with various small-bowel disorders. The yield of CE for indications of disorders other than GI bleeding is not yet well described. The aim of the present study was to determine in which subgroup of patients with unexplained abdominal pain, CE would be a helpful evaluation tool. Material and methods . The results of CE in 110 patients (70 M, 40 F, mean age 50.8±14.1 years) with unexplained abdominal pain from 12 tertiary referral centers between September 2002 and September 2004 were retrospectively analyzed. Results. The visualization of the small bowel to the cecum was successfully carried out in 69.1% of the patients. Nineteen out of the 110 cases revealed positive findings that explained the symptoms of the patient (diagnostic yield = 17.3%). Diagnosis included small-bowel stricture (5), Crohn's disease (3), small-bowel tumor (2), radiation-induced enteritis (1), NSAID-induced enteropathy (1), ischemic ileitis (1), diffuse lymphangiectasia (1), and significant erosion or ulceration (5). By univariate logistic regression analysis, the positive findings of CE were significantly associated with weight loss (odds ratio (OR), 11.9; 95% CI [2.0, 70.6]), elevated erythrocyte sedimentation rate (ESR)(>20 mm/h) (OR, 11.5; 95% CI (1.9, 69.5)), elevated C-reactive protein (CRP) (≥0.4 mg/dL) (OR, 5.0; 95% CI (1.6, 15.9)), and hypoalbuminemia (albumin <3 g/dL) (OR, 23.1; 95% CI (2.4,223.1)). Using a multivariate analysis, weight loss was found to be a significant risk factor for positive findings of CE (OR, 18.6; 95% CI (1.6, 222.4), p = 0.02). Conclusions. The results of this study suggest that CE can be helpful in patients suffering from abdominal pain that cannot be explained by established examinations, if the pain is accompanied by weight loss.
KW - Abdominal pain
KW - Capsule endoscopy
UR - http://www.scopus.com/inward/record.url?scp=33745684510&partnerID=8YFLogxK
U2 - 10.1080/00365520600548974
DO - 10.1080/00365520600548974
M3 - Article
C2 - 16803698
AN - SCOPUS:33745684510
SN - 0036-5521
VL - 41
SP - 983
EP - 988
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 8
ER -