A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Xiaolong Sun, Gyoungmi Kim, Yufang Xu, Juyoung Yoon, Tony D. James

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalChemPlusChem
Volume81
Issue number1
DOIs
StatePublished - 1 Jan 2016

Bibliographical note

Funding Information:
T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities.

Funding Information:
T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities .

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • cell imaging
  • copper
  • fluorescence probes
  • nitric oxide
  • nitroxyl

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