A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Xiaolong Sun; Gyoungmi Kim; Yufang Xu; Juyoung Yoon; Tony D. James

doi:10.1002/cplu.201500436

A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Xiaolong Sun, Gyoungmi Kim, Yufang Xu, Juyoung Yoon, Tony D. James

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	ChemPlusChem
Volume	81
Issue number	1
DOIs	https://doi.org/10.1002/cplu.201500436
State	Published - 1 Jan 2016

Bibliographical note

Funding Information:
T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities.

Funding Information:
T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities .

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

cell imaging
copper
fluorescence probes
nitric oxide
nitroxyl

Access to Document

10.1002/cplu.201500436

Cite this

@article{c5927f1735bd408493415df871bd9a88,

title = "A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells",

abstract = "A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).",

keywords = "cell imaging, copper, fluorescence probes, nitric oxide, nitroxyl",

author = "Xiaolong Sun and Gyoungmi Kim and Yufang Xu and Juyoung Yoon and James, {Tony D.}",

note = "Funding Information: T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. Funding Information: T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities . Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = jan,

day = "1",

doi = "10.1002/cplu.201500436",

language = "English",

volume = "81",

pages = "30--34",

journal = "ChemPlusChem",

issn = "2192-6506",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

AU - Sun, Xiaolong

AU - Kim, Gyoungmi

AU - Xu, Yufang

AU - Yoon, Juyoung

AU - James, Tony D.

N1 - Funding Information: T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. Funding Information: T.D.J. and X.S. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. J.Y. acknowledges financial support from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities . Publisher Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

AB - A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

KW - cell imaging

KW - copper

KW - fluorescence probes

KW - nitric oxide

KW - nitroxyl

UR - http://www.scopus.com/inward/record.url?scp=85000624290&partnerID=8YFLogxK

U2 - 10.1002/cplu.201500436

DO - 10.1002/cplu.201500436

M3 - Article

AN - SCOPUS:85000624290

SN - 2192-6506

VL - 81

SP - 30

EP - 34

JO - ChemPlusChem

JF - ChemPlusChem

IS - 1

ER -

A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this