A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Liyan Chen; Di Wu; Chang Su Lim; Dayoung Kim; Sang Jip Nam; Woolin Lee; Gyungmi Kim; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/c7cc01695f

A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Liyan Chen, Di Wu, Chang Su Lim, Dayoung Kim, Sang Jip Nam, Woolin Lee, Gyungmi Kim, Hwan Myung Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Hydrogen sulfide (H₂S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a "turn-on" fluorescent probe for H₂S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H₂S. Furthermore, the probe was successfully utilized to detect H₂S in HeLa cells with both one-photon and two-photon microscopy.

Original language	English
Pages (from-to)	4791-4794
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	35
DOIs	https://doi.org/10.1039/c7cc01695f
State	Published - 2017

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This journal is © The Royal Society of Chemistry.

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abstract = "Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a {"}turn-on{"} fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.",

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AU - Chen, Liyan

AU - Wu, Di

AU - Lim, Chang Su

AU - Kim, Dayoung

AU - Nam, Sang Jip

AU - Lee, Woolin

AU - Kim, Gyungmi

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

PY - 2017

Y1 - 2017

N2 - Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a "turn-on" fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.

AB - Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a "turn-on" fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.

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SN - 1359-7345

VL - 53

SP - 4791

EP - 4794

JO - Chemical Communications

JF - Chemical Communications

IS - 35

ER -

A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Abstract

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