A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics

Liyan Chen, Di Wu, Chang Su Lim, Dayoung Kim, Sang Jip Nam, Woolin Lee, Gyungmi Kim, Hwan Myung Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a "turn-on" fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.

Original languageEnglish
Pages (from-to)4791-4794
Number of pages4
JournalChemical Communications
Volume53
Issue number35
DOIs
StatePublished - 2017

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