A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite

Liyan Chen; Sang Jun Park; Di Wu; Hwan Myung Kim; Juyoung Yoon

doi:10.1016/j.dyepig.2018.01.027

A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite

Liyan Chen, Sang Jun Park, Di Wu, Hwan Myung Kim, Juyoung Yoon

Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy.

Original language	English
Pages (from-to)	526-532
Number of pages	7
Journal	Dyes and Pigments
Volume	158
DOIs	https://doi.org/10.1016/j.dyepig.2018.01.027
State	Published - Nov 2018

Keywords

ESIPT
Hypochlorite
Living cells
Tissue imaging
Two-photon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2018.01.027

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title = "A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite",

abstract = "Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy.",

keywords = "ESIPT, Hypochlorite, Living cells, Tissue imaging, Two-photon",

author = "Liyan Chen and Park, {Sang Jun} and Di Wu and Kim, {Hwan Myung} and Juyoung Yoon",

note = "Funding Information: This study was supported by grants of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) ( 2012R1A3A2048814 to J. Y.; 2016R1E1A1A02920873 to H. M. K) Mass spectral data were ob-tained from the Korea Basic Science Institute (Daegu) using a Jeol JMS 700 high-resolution mass spectrometer. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = nov,

doi = "10.1016/j.dyepig.2018.01.027",

language = "English",

volume = "158",

pages = "526--532",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier BV",

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TY - JOUR

T1 - A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite

AU - Chen, Liyan

AU - Park, Sang Jun

AU - Wu, Di

AU - Kim, Hwan Myung

AU - Yoon, Juyoung

N1 - Funding Information: This study was supported by grants of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) ( 2012R1A3A2048814 to J. Y.; 2016R1E1A1A02920873 to H. M. K) Mass spectral data were ob-tained from the Korea Basic Science Institute (Daegu) using a Jeol JMS 700 high-resolution mass spectrometer. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/11

Y1 - 2018/11

N2 - Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy.

AB - Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy.

KW - ESIPT

KW - Hypochlorite

KW - Living cells

KW - Tissue imaging

KW - Two-photon

UR - http://www.scopus.com/inward/record.url?scp=85041624540&partnerID=8YFLogxK

U2 - 10.1016/j.dyepig.2018.01.027

DO - 10.1016/j.dyepig.2018.01.027

M3 - Article

AN - SCOPUS:85041624540

VL - 158

SP - 526

EP - 532

JO - Dyes and Pigments

JF - Dyes and Pigments

SN - 0143-7208

ER -

A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite

Abstract

Keywords

UN SDGs

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