A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite

Liyan Chen, Sang Jun Park, Di Wu, Hwan Myung Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy.

Original languageEnglish
Pages (from-to)526-532
Number of pages7
JournalDyes and Pigments
StatePublished - Nov 2018

Bibliographical note

Funding Information:
This study was supported by grants of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) ( 2012R1A3A2048814 to J. Y.; 2016R1E1A1A02920873 to H. M. K) Mass spectral data were ob-tained from the Korea Basic Science Institute (Daegu) using a Jeol JMS 700 high-resolution mass spectrometer.

Publisher Copyright:
© 2018 Elsevier Ltd


  • Hypochlorite
  • Living cells
  • Tissue imaging
  • Two-photon


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