Abstract
A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 3777-3781 |
| Number of pages | 5 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 34 |
| Issue number | 12 |
| DOIs | |
| State | Published - 20 Dec 2013 |
Keywords
- Aliskiren
- D-Tartrate diester
- Symmetric precursor
- Total synthesis