A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
|Number of pages||5|
|Journal||Bulletin of the Korean Chemical Society|
|State||Published - 20 Dec 2013|
- D-Tartrate diester
- Symmetric precursor
- Total synthesis