A total synthesis of aliskiren

Gyeok Nam; Soo Y. Ko

doi:10.1002/hlca.201200425

A total synthesis of aliskiren

Gyeok Nam, Soo Y. Ko

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A total synthesis of aliskiren (20) was accomplished. A key in our synthesis was to use the symmetric trans-cisoid-trans-bis-lactone 1 as a precursor. It was expediently prepared by three different routes (Scheme 2). Appending the end groups and functional group transformations completed the synthesis (Scheme 3).

Original language	English
Pages (from-to)	1937-1945
Number of pages	9
Journal	Helvetica Chimica Acta
Volume	95
Issue number	10
DOIs	https://doi.org/10.1002/hlca.201200425
State	Published - Oct 2012

Keywords

Aliskiren

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10.1002/hlca.201200425

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title = "A total synthesis of aliskiren",

abstract = "A total synthesis of aliskiren (20) was accomplished. A key in our synthesis was to use the symmetric trans-cisoid-trans-bis-lactone 1 as a precursor. It was expediently prepared by three different routes (Scheme 2). Appending the end groups and functional group transformations completed the synthesis (Scheme 3).",

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AB - A total synthesis of aliskiren (20) was accomplished. A key in our synthesis was to use the symmetric trans-cisoid-trans-bis-lactone 1 as a precursor. It was expediently prepared by three different routes (Scheme 2). Appending the end groups and functional group transformations completed the synthesis (Scheme 3).

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M3 - Article

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EP - 1945

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 10

ER -

A total synthesis of aliskiren

Abstract

Keywords

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