A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model

Lei Zhang; Yong Zhang; Chul Koo Kim; Kong Ju Bock Lee

doi:10.1142/S0217984912500807

A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model

Lei Zhang, Yong Zhang, Chul Koo Kim, Kong Ju Bock Lee

Department of Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding the nonlinear capacitance (NLC) of prestin and outer hair cell (OHC) is important for exploring the activity of mammalian cochlea. After introducing a nontransporting five-state model of the OHC motor which is the tetramer of prestin, we obtain the peak of the NLC of OHC and the peak shift of the NLC as functions of the concentration of the intracellular Cl ^- anions. By employing the same model, we calculate the frequency dependence of the NLC as well. The model results both in equilibrium state and of the frequency dependence agree with the experimental observations. Accordingly, it suggests that the introduced five-state model is a candidate for exploring the NLC of both OHC and prestin.

Original language	English
Article number	1250080
Journal	Modern Physics Letters B
Volume	26
Issue number	13
DOIs	https://doi.org/10.1142/S0217984912500807
State	Published - 30 May 2012

Bibliographical note

Funding Information:
For funding, we thank the National Natural Science Foundation of China (NSFC Nos. 11004255 and 11004256).

Keywords

Nonlinear capacitance
nontransporting model
outer hair cell
prestin

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10.1142/S0217984912500807

Cite this

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title = "A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model",

abstract = "Understanding the nonlinear capacitance (NLC) of prestin and outer hair cell (OHC) is important for exploring the activity of mammalian cochlea. After introducing a nontransporting five-state model of the OHC motor which is the tetramer of prestin, we obtain the peak of the NLC of OHC and the peak shift of the NLC as functions of the concentration of the intracellular Cl - anions. By employing the same model, we calculate the frequency dependence of the NLC as well. The model results both in equilibrium state and of the frequency dependence agree with the experimental observations. Accordingly, it suggests that the introduced five-state model is a candidate for exploring the NLC of both OHC and prestin.",

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author = "Lei Zhang and Yong Zhang and Kim, {Chul Koo} and Lee, {Kong Ju Bock}",

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T1 - A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model

AU - Zhang, Lei

AU - Zhang, Yong

AU - Kim, Chul Koo

AU - Lee, Kong Ju Bock

N1 - Funding Information: For funding, we thank the National Natural Science Foundation of China (NSFC Nos. 11004255 and 11004256).

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AB - Understanding the nonlinear capacitance (NLC) of prestin and outer hair cell (OHC) is important for exploring the activity of mammalian cochlea. After introducing a nontransporting five-state model of the OHC motor which is the tetramer of prestin, we obtain the peak of the NLC of OHC and the peak shift of the NLC as functions of the concentration of the intracellular Cl - anions. By employing the same model, we calculate the frequency dependence of the NLC as well. The model results both in equilibrium state and of the frequency dependence agree with the experimental observations. Accordingly, it suggests that the introduced five-state model is a candidate for exploring the NLC of both OHC and prestin.

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A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model

Abstract

Bibliographical note

Keywords

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