A theoretical model for immobilized whole cell enzyme

Ho Nam Chang, Tai Hyun Park

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A method of estimating effectiveness factor for immobilized whole cells is developed by considering microbial cells as microspheres containing enzyme activity dispersed in the gel phase of the support matrix. The proper model equations describing the system are solved and the corresponding effectiveness factors calculated for various bead sizes, and numbers and activities of cells. The cell wall resistance (permeability) is found to be one of most important variables in the system. The model is applied in predicting the experimental data of other investigators.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalJournal of Theoretical Biology
Issue number1
StatePublished - 7 Sep 1985


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