A tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery

Yong Joo Jun, Jung Hee Kim, Su Jin Choi, Hwa Jeong Lee, Moo Jin Jun, Youn Soo Sohn

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(l-lysine), LysLys(LysEt)2, as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes.

Original languageEnglish
Pages (from-to)2975-2978
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number11
DOIs
StatePublished - 1 Jun 2007

Keywords

  • Lysine
  • Non-viral vector
  • Polyphosphazene
  • Polyplex

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