A synthesis of oseltamivir (Tamiflu) starting from D-mannitol.

J. S. Ko; J. E. Keum; Soo Y. Ko

doi:10.1021/jo101517g

A synthesis of oseltamivir (Tamiflu) starting from D-mannitol.

J. S. Ko, J. E. Keum, Soo Y. Ko

Department of Chemistry & Nanoscience

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45 Scopus citations

Abstract

A synthesis of oseltamivir (Tamiflu) was achieved starting from D-mannitol. A unique feature of the synthetic route is that an acyclic precursor was constructed, which was then cyclized in an intramolecular aldol reaction to form the Tamiflu skeleton. Throughout the synthesis, well-established, highly efficient reactions were employed, and no protection/deprotection sequence was needed.

Original language	English
Pages (from-to)	7006-7009
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	75
Issue number	20
DOIs	https://doi.org/10.1021/jo101517g
State	Published - 15 Oct 2010

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A synthesis of oseltamivir (Tamiflu) starting from D-mannitol.

Abstract

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