A synthesis of oseltamivir (Tamiflu) starting from D-mannitol.

J. S. Ko, J. E. Keum, Soo Y. Ko

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42 Scopus citations

Abstract

A synthesis of oseltamivir (Tamiflu) was achieved starting from D-mannitol. A unique feature of the synthetic route is that an acyclic precursor was constructed, which was then cyclized in an intramolecular aldol reaction to form the Tamiflu skeleton. Throughout the synthesis, well-established, highly efficient reactions were employed, and no protection/deprotection sequence was needed.

Original languageEnglish
Pages (from-to)7006-7009
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number20
DOIs
StatePublished - 15 Oct 2010

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