@article{7f99c3655fe548558f8417e470628615,
title = "A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria",
abstract = "With the ever-increasing threat posed by the multi-drug resistance of bacteria, the development of non-antibiotic agents for the broad-spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self-assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties with significant reactive-oxygen-species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram-positive, Gram-negative, and drug-resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual-modal antimicrobial agents that are able to overcome antibiotic resistance.",
keywords = "antimicrobial activity, graphene nanoribbons, phototherapy, porphyrin, supramolecular structures",
author = "Yu, {Zhi Hao} and Xingshu Li and Fugui Xu and Hu, {Xi Le} and Jiatao Yan and Nahyun Kwon and Chen, {Guo Rong} and Tingting Tang and Xiaojing Dong and Yiyong Mai and Daijie Chen and Juyoung Yoon and He, {Xiao Peng} and He Tian",
note = "Funding Information: The authors thank Prof. Xinliang Feng at Technische Universit{\"a}t Dresden for help with some measurements. A. C. Sedgwick at UT Austin is appreciated for help in editing this manuscript. Financial support from the Natural Science Foundation of China (21788102, 91853201, 21774076, 51573091, 21722801 and 21776078), the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (2012R1A3A2048814), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Program of Shanghai Academic Research Leader (19XD1421700), and the Program of Shanghai Eastern Scholar are gratefully acknowledged. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. Funding Information: The authors thank Prof. Xinliang Feng at Technische Universit?t Dresden for help with some measurements. A. C. Sedgwick at UT Austin is appreciated for help in editing this manuscript. Financial support from the Natural Science Foundation of China (21788102, 91853201, 21774076, 51573091, 21722801 and 21776078), the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (2012R1A3A2048814), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Program of Shanghai Academic Research Leader (19XD1421700), and the Program of Shanghai Eastern Scholar are gratefully acknowledged. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = feb,
day = "24",
doi = "10.1002/anie.201913506",
language = "English",
volume = "59",
pages = "3658--3664",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "9",
}