A                         1                          adenosine receptor agonists, antagonists, and allosteric modulators

Zhan Guo Gao; Dilip K. Tosh; Shanu Jain; Jinha Yu; Rama R. Suresh; Kenneth A. Jacobson

doi:10.1007/978-3-319-90808-3_4

A ₁ adenosine receptor agonists, antagonists, and allosteric modulators

Zhan Guo Gao, Dilip K. Tosh, Shanu Jain, Jinha Yu, Rama R. Suresh, Kenneth A. Jacobson

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

One of the four G protein-coupled receptors for adenosine, the A ₁ adenosine receptors (A ₁ AR), is widely distributed in the body and modulates numerous normal and pathological processes, through signaling pathways including those downstream from its coupled G _i protein. It is an attractive drug target for heart failure, arrhythmias, angina, asthma, stroke, seizure, pain, depression, and diabetes. In this chapter, we describe the A ₁ AR structure, function, signaling pathways, and therapeutic applications. We detail numerous structure-activity features of A ₁ AR agonists, antagonists, and allosteric modulators, introduced as pharmacological tools and molecules for clinical development.

Original language	English
Pages (from-to)	59-89
Number of pages	31
Journal	Receptors
Volume	34
DOIs	https://doi.org/10.1007/978-3-319-90808-3_4
State	Published - 2018

Keywords

A adenosine receptors
A AR agonists and antagonists
A AR allosteric modulators
A AR structural characterization
Structure-activity relationships

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-90808-3_4

Cite this

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title = " A 1 adenosine receptor agonists, antagonists, and allosteric modulators ",

abstract = " One of the four G protein-coupled receptors for adenosine, the A 1 adenosine receptors (A 1 AR), is widely distributed in the body and modulates numerous normal and pathological processes, through signaling pathways including those downstream from its coupled G i protein. It is an attractive drug target for heart failure, arrhythmias, angina, asthma, stroke, seizure, pain, depression, and diabetes. In this chapter, we describe the A 1 AR structure, function, signaling pathways, and therapeutic applications. We detail numerous structure-activity features of A 1 AR agonists, antagonists, and allosteric modulators, introduced as pharmacological tools and molecules for clinical development. ",

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AU - Tosh, Dilip K.

AU - Jain, Shanu

AU - Yu, Jinha

AU - Suresh, Rama R.

AU - Jacobson, Kenneth A.

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