A straightforward synthesis of K-7174, a GATA-specific inhibitor

Mahesh S. Majik, Jin Ha Yu, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. An expeditious four-step synthesis of K-7174 is described in this paper. The route employs Wittig olefination and bis-alkylation of homopiperazine as the key reactions. The iodinecatalyzed isomerization of the Z-isomer results in complete conversion to the E-isomer is the highlight of our synthetic endeavors.

Original languageEnglish
Pages (from-to)2903-2906
Number of pages4
JournalBulletin of the Korean Chemical Society
Issue number9
StatePublished - 20 Sep 2012


  • GATA-inhibitor
  • Iodine-catalyzed isomerization
  • K-7174
  • Wittig reaction


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