TY - JOUR
T1 - A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity
AU - Jung, Jae Chul
AU - Min, Dongguk
AU - Lim, Heena
AU - Moon, Sohyeon
AU - Jung, Mankil
AU - Oh, Seikwan
N1 - Funding Information:
Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MEST) (MRC, 2010-0029355).
PY - 2013/10
Y1 - 2013/10
N2 - A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.
AB - A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.
KW - Antinarcotic activity
KW - Antineurotoxicity
KW - Condensation reaction
KW - Coupling reaction
KW - Free radical scavenging
KW - Trans-3,4,5-trimethoxycinnamamides
UR - http://www.scopus.com/inward/record.url?scp=84883464161&partnerID=8YFLogxK
U2 - 10.1007/s00044-012-0415-1
DO - 10.1007/s00044-012-0415-1
M3 - Article
AN - SCOPUS:84883464161
SN - 1054-2523
VL - 22
SP - 4615
EP - 4621
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
IS - 10
ER -