A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity

Jae Chul Jung, Dongguk Min, Heena Lim, Sohyeon Moon, Mankil Jung, Seikwan Oh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.

Original languageEnglish
Pages (from-to)4615-4621
Number of pages7
JournalMedicinal Chemistry Research
Volume22
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • Antinarcotic activity
  • Antineurotoxicity
  • Condensation reaction
  • Coupling reaction
  • Free radical scavenging
  • Trans-3,4,5-trimethoxycinnamamides

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