A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity

Jae Chul Jung; Dongguk Min; Heena Lim; Sohyeon Moon; Mankil Jung; Seikwan Oh

doi:10.1007/s00044-012-0415-1

A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity

Jae Chul Jung, Dongguk Min, Heena Lim, Sohyeon Moon, Mankil Jung, Seikwan Oh

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.

Original language	English
Pages (from-to)	4615-4621
Number of pages	7
Journal	Medicinal Chemistry Research
Volume	22
Issue number	10
DOIs	https://doi.org/10.1007/s00044-012-0415-1
State	Published - Oct 2013

Bibliographical note

Funding Information:
Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MEST) (MRC, 2010-0029355).

Keywords

Antinarcotic activity
Antineurotoxicity
Condensation reaction
Coupling reaction
Free radical scavenging
Trans-3,4,5-trimethoxycinnamamides

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10.1007/s00044-012-0415-1

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title = "A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity",

abstract = "A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.",

keywords = "Antinarcotic activity, Antineurotoxicity, Condensation reaction, Coupling reaction, Free radical scavenging, Trans-3,4,5-trimethoxycinnamamides",

author = "Jung, {Jae Chul} and Dongguk Min and Heena Lim and Sohyeon Moon and Mankil Jung and Seikwan Oh",

note = "Funding Information: Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MEST) (MRC, 2010-0029355).",

year = "2013",

month = oct,

doi = "10.1007/s00044-012-0415-1",

language = "English",

volume = "22",

pages = "4615--4621",

journal = "Medicinal Chemistry Research",

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T1 - A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity

AU - Jung, Jae Chul

AU - Min, Dongguk

AU - Lim, Heena

AU - Moon, Sohyeon

AU - Jung, Mankil

AU - Oh, Seikwan

N1 - Funding Information: Acknowledgments This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MEST) (MRC, 2010-0029355).

PY - 2013/10

Y1 - 2013/10

N2 - A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.

AB - A simple synthesis and biologic evaluation of trans-3,4,5- trimethoxycinnamamides 10a-e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3,4,5-trimethoxycinnamamides 10a-e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It was found that compounds 10a, 10d, and 10e displayed significant inhibitory action of the glutamate-induced neurotoxicity and 10a-e and 11 showed high antinarcotic activity in mice.

KW - Antinarcotic activity

KW - Antineurotoxicity

KW - Condensation reaction

KW - Coupling reaction

KW - Free radical scavenging

KW - Trans-3,4,5-trimethoxycinnamamides

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U2 - 10.1007/s00044-012-0415-1

DO - 10.1007/s00044-012-0415-1

M3 - Article

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SN - 1054-2523

VL - 22

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EP - 4621

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 10

ER -

A simple synthesis of trans-3,4,5-trimethoxycinnamamides and evaluation of their biologic activity

Abstract

Bibliographical note

Keywords

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