Abstract
A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [11C]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [11C]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [11C]methionine solution using an anion-exchange resin cartridge.
Original language | English |
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Pages (from-to) | 933-939 |
Number of pages | 7 |
Journal | Journal of Radioanalytical and Nuclear Chemistry |
Volume | 322 |
Issue number | 2 |
DOIs | |
State | Published - 1 Nov 2019 |
Bibliographical note
Funding Information:We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).
Funding Information:
We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).
Publisher Copyright:
© 2019, Akadémiai Kiadó, Budapest, Hungary.
Keywords
- Anion-exchange resin cartridge
- Iodine impurity
- L-[S-methyl-C]methionine
- [C]Radiopharmaceuticals