A simple decontamination procedure for unintended iodide impurity during [11C]methionine production

Hyun Sik Park; Byung Seok Moon; Hong Jin Lee; Hyun Ho An; Bom Sahn Kim; Won Woo Lee; Sang Eun Kim; Byung Chul Lee

doi:10.1007/s10967-019-06757-6

A simple decontamination procedure for unintended iodide impurity during [¹¹C]methionine production

Hyun Sik Park, Byung Seok Moon, Hong Jin Lee, Hyun Ho An, Bom Sahn Kim, Won Woo Lee, Sang Eun Kim, Byung Chul Lee

Department of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [¹¹C]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [¹¹C]CH₃I production. Herein, we suggest a simple method to eliminate impurities contained in [¹¹C]methionine solution using an anion-exchange resin cartridge.

Original language	English
Pages (from-to)	933-939
Number of pages	7
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	322
Issue number	2
DOIs	https://doi.org/10.1007/s10967-019-06757-6
State	Published - 1 Nov 2019

Bibliographical note

Funding Information:
We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).

Funding Information:
We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).

Publisher Copyright:
© 2019, Akadémiai Kiadó, Budapest, Hungary.

Keywords

Anion-exchange resin cartridge
Iodine impurity
L-[S-methyl-C]methionine
[C]Radiopharmaceuticals

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10.1007/s10967-019-06757-6

Cite this

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title = "A simple decontamination procedure for unintended iodide impurity during [11C]methionine production",

abstract = "A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [11C]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [11C]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [11C]methionine solution using an anion-exchange resin cartridge.",

keywords = "Anion-exchange resin cartridge, Iodine impurity, L-[S-methyl-C]methionine, [C]Radiopharmaceuticals",

author = "Park, {Hyun Sik} and Moon, {Byung Seok} and Lee, {Hong Jin} and An, {Hyun Ho} and Kim, {Bom Sahn} and Lee, {Won Woo} and Kim, {Sang Eun} and Lee, {Byung Chul}",

note = "Funding Information: We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284). Funding Information: We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284). Publisher Copyright: {\textcopyright} 2019, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

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AU - Kim, Bom Sahn

AU - Lee, Won Woo

AU - Kim, Sang Eun

AU - Lee, Byung Chul

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