A shortcut to carbon-neutral bioplastic production: Recent advances in microbial production of polyhydroxyalkanoates from C1 resources

Seo Young Jo, Jina Son, Yu Jung Sohn, Seo Hyun Lim, Ji Yeon Lee, Jee In Yoo, Se Young Park, Jeong Geol Na, Si Jae Park

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Since the 20th century, plastics that are widely being used in general life and industries are causing enormous plastic waste problems since improperly discarded plastics barely degrade and decompose. Thus, the demand for polyhydroxyalkanoates (PHAs), biodegradable polymers with material properties similar to conventional petroleum-based plastics, has been increased so far. The microbial production of PHAs is an environment-friendly solution for the current plastic crisis, however, the carbon sources for the microbial PHA production is a crucial factor to be considered in terms of carbon-neutrality. One‑carbon (C1) resources, such as methane, carbon monoxide, and carbon dioxide, are greenhouse gases and are abundantly found in nature and industry. C1 resources as the carbon sources for PHA production have a completely closed carbon loop with much advances; i) fast carbon circulation with direct bioconversion process and ii) simple fermentation procedure without sterilization as non-preferable nutrients. This review discusses the biosynthesis of PHAs based on C1 resource utilization by wild-type and metabolically engineered microbial host strains via biorefinery processes.

Original languageEnglish
Pages (from-to)978-998
Number of pages21
JournalInternational Journal of Biological Macromolecules
Volume192
DOIs
StatePublished - 1 Dec 2021

Bibliographical note

Funding Information:
This work was supported by the C1 Gas Refinery Program from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea ( NRF-2018 M3D3A1A01017988 ) and the NRF grant funded by the MSIT ( NRF-2020R1A5A1019631 ). Seo Young Jo appreciates the supports from Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2020R1A6A3A13076727 ) and the Ewha Womans University scholarship of 2020.

Publisher Copyright:
© 2021

Keywords

  • C1 resources
  • Carbon-neutrality
  • Polyhydroxyalkanoates

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