A selenolactone-based fluorescent chemodosimeter to monitor mecury/methylmercury species in vitro and in vivo

Xiaoqiang Chen, Kyung Hwa Baek, Youngmee Kim, Sung Jin Kim, Injae Shin, Juyoung Yoon

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121 Scopus citations

Abstract

A fluorescent probe based on selenolactone displays unique fluorescence enhancement and UV-vis spectral change for mercury/methylmercury species, which were attributed to deselenation reaction. The value of this system was successfully demonstrated by its use in detecting inorganic mercury/methylmercury species in cells and zebrafish.

Original languageEnglish
Pages (from-to)4016-4021
Number of pages6
JournalTetrahedron
Volume66
Issue number23
DOIs
StatePublished - 5 Jun 2010

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Research Foundation Grant ( KRF-2006-005-J04002 ), the National Research Foundation of Korea ( NRF ) ( 20090083065 ), the National Creative Research Initiative and WCU ( R32-2008-000-10217-0 ) programs. Mass spectra data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.

Keywords

  • Fluorescent chemodosimeter
  • Mecury
  • Methylmercury
  • Rhodamine
  • Selenolactone

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