A selective 'Off-On' fluorescent sensor for Zn2+ based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn2+

Ying Zhou; Ha Na Kim; Juyoung Yoon

doi:10.1016/j.bmcl.2009.11.028

A selective 'Off-On' fluorescent sensor for Zn²⁺ based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn²⁺

Ying Zhou
, Ha Na Kim
, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

A simple and effective fluorescent sensor based on hydrazone-pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn²⁺, and application of this probe to detect the intrinsic Zn²⁺ ions present in pancreatic β-cells was successfully demonstrated.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2009.11.028
State	Published - 1 Jan 2010

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 20090083065 , 20090063001 ) and WCU program (R32-2008-000-10180-0).

Keywords

Fluorescent chemosensor
Fluorescent probe
Pyrene
Zinc sensor

Access to Document

10.1016/j.bmcl.2009.11.028

Cite this

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abstract = "A simple and effective fluorescent sensor based on hydrazone-pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn2+, and application of this probe to detect the intrinsic Zn2+ ions present in pancreatic β-cells was successfully demonstrated.",

keywords = "Fluorescent chemosensor, Fluorescent probe, Pyrene, Zinc sensor",

author = "Ying Zhou and Kim, \{Ha Na\} and Juyoung Yoon",

note = "Funding Information: This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 20090083065 , 20090063001 ) and WCU program (R32-2008-000-10180-0). ",

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KW - Fluorescent probe

KW - Pyrene

KW - Zinc sensor

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