A review: The trend of progress about pH probes in cell application in recent years

Yongkang Yue, Fangjun Huo, Songyi Lee, Caixia Yin, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations

Abstract

Intracellular pH values are some of the most important factors that govern biological processes and the acid-base homeostasis in cells, body fluids and organs sustains the normal operations of the body. Subcellular organelles including the acidic lysosomes and the alkalescent mitochondria undergo various processes such as intracellular digestion, ATP production and apoptosis. Due to their precise imaging capabilities, fluorescent probes have attracted great attention for the illustration of pH modulated processes. Furthermore, based on the unique acidic extracellular environment of acidic lysosomes, fluorescent probes can specifically be activated in cancer cells or tumors. In this review, recently reported lysosome and mitochondria specific pH imaging probes as well as pH-activatable cancer cell-targetable probes have been discussed.

Original languageEnglish
Pages (from-to)30-41
Number of pages12
JournalAnalyst
Volume142
Issue number1
DOIs
StatePublished - 7 Jan 2017

Fingerprint

Dive into the research topics of 'A review: The trend of progress about pH probes in cell application in recent years'. Together they form a unique fingerprint.

Cite this