A regulatory role for TRAF1 in antigen-induced apoptosis of T cells

Daniel E. Speiser, Soo Young Lee, Brian Wong, Joseph Arron, Angela Santana, Young Yun Kong, Pamela S. Ohashi, Yongwon Choi

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-κB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8+ T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily.

Original languageEnglish
Pages (from-to)1777-1783
Number of pages7
JournalJournal of Experimental Medicine
Volume185
Issue number10
DOIs
StatePublished - 19 May 1997

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