TY - JOUR
T1 - A Prospective Phase II Trial of Induction Chemotherapy with Docetaxel/Cisplatin for Masaoka Stage III/IV thymic Epithelial Tumors
AU - Park, Silvia
AU - Ahn, Myung Ju
AU - Ahn, Jin Seok
AU - Sun, Jong Mu
AU - Shim, Young Mog
AU - Kim, Jhingook
AU - Choi, Yong Soo
AU - Kim, Kwhanmien
AU - Shin, Sumin
AU - Ahn, Yongchan
AU - Kwon, O. Jung
AU - Kim, Hojoong
AU - Lee, Su Jin
AU - Chang, Won Jin
AU - Park, Keunchil
N1 - Funding Information:
This study was sponsored by Sanofi Aventis; the company provided a free supply of the docetaxel .
PY - 2013/7
Y1 - 2013/7
N2 - BACKGROUND:: Initial complete resection is a powerful prognostic indicator of survival in thymic epithelial tumors (TETs), but is obviously related to tumor stage. Here, we report the results of a prospective study of neoadjuvant docetaxel/cisplatin in locally advanced TETs. METHODS:: Patients with histologically proven, Masaoka stage III/IV TETs at presentation were enrolled in this open-label, phase II, nonrandomized study. Patients received docetaxel 75 mg/m I.V, followed by cisplatin 75 mg/m I.V on day 1 of every 3-week cycle. After three cycles, surgical resection was performed if the tumor was considered resectable. RESULTS:: From March 2007 to July 2011, 27 patients were enrolled in the trial. Masaoka stage at presentation was III (n = 8; 29.6%), IVA (n = 17; 63.0%), and IVB (n = 2; 7.4%). Histologic types were nine thymomas (33.3%) and 18 thymic carcinomas (66.7%). After completion of neoadjuvant chemotherapy, 17 patients (63.0%) achieved partial response and 10 (37.0%) had stable disease. Nineteen patients (70.4%) underwent surgery and eight did not because of surgeons' decision (n = 5), patient refusal (n = 2), or decision to undergo radiation therapy instead (n = 1). Fifteen among the 19 patients achieved complete resection (78.9%), which yields 55.6% of complete resection rate with intent-to-treat analysis. The most common side effects of severity greater than grade 3 were neutropenia and diarrhea. With a median follow-up of 42.6 months, 4-year overall survival, and progression-free survival in all patients was 79.4 and 40.6%, respectively. CONCLUSION:: Neoadjuvant docetaxel/cisplatin is both feasible and well tolerated, and potentially improves surgical resectability in patients with advanced TETs.
AB - BACKGROUND:: Initial complete resection is a powerful prognostic indicator of survival in thymic epithelial tumors (TETs), but is obviously related to tumor stage. Here, we report the results of a prospective study of neoadjuvant docetaxel/cisplatin in locally advanced TETs. METHODS:: Patients with histologically proven, Masaoka stage III/IV TETs at presentation were enrolled in this open-label, phase II, nonrandomized study. Patients received docetaxel 75 mg/m I.V, followed by cisplatin 75 mg/m I.V on day 1 of every 3-week cycle. After three cycles, surgical resection was performed if the tumor was considered resectable. RESULTS:: From March 2007 to July 2011, 27 patients were enrolled in the trial. Masaoka stage at presentation was III (n = 8; 29.6%), IVA (n = 17; 63.0%), and IVB (n = 2; 7.4%). Histologic types were nine thymomas (33.3%) and 18 thymic carcinomas (66.7%). After completion of neoadjuvant chemotherapy, 17 patients (63.0%) achieved partial response and 10 (37.0%) had stable disease. Nineteen patients (70.4%) underwent surgery and eight did not because of surgeons' decision (n = 5), patient refusal (n = 2), or decision to undergo radiation therapy instead (n = 1). Fifteen among the 19 patients achieved complete resection (78.9%), which yields 55.6% of complete resection rate with intent-to-treat analysis. The most common side effects of severity greater than grade 3 were neutropenia and diarrhea. With a median follow-up of 42.6 months, 4-year overall survival, and progression-free survival in all patients was 79.4 and 40.6%, respectively. CONCLUSION:: Neoadjuvant docetaxel/cisplatin is both feasible and well tolerated, and potentially improves surgical resectability in patients with advanced TETs.
KW - Docetaxel/cisplatin
KW - Preoperative chemotherapy
KW - Resectability
KW - Thymic tumor
UR - http://www.scopus.com/inward/record.url?scp=84880924991&partnerID=8YFLogxK
U2 - 10.1097/JTO.0b013e318292c41e
DO - 10.1097/JTO.0b013e318292c41e
M3 - Article
C2 - 23722169
AN - SCOPUS:84880924991
SN - 1556-0864
VL - 8
SP - 959
EP - 966
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 7
ER -