A prodrug approach to COX-2 inhibitors with methylsulfone

Joo Hyun Moh, Young Hoon Choi, Kyoung Min Lim, Ki Wha Lee, Song Seok Shin, Jin Kyu Choi, Hyun Joo Koh, Shin Chung

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

2,2-Dimethyl-4-phenyl-5-{4-(methylsulfinyl)phenyl}-3(2H)furanone derivatives, 3 and 6, were shown to be effectively transformed in vivo into the corresponding methylsulfone derivatives 1 and 4, when orally administered to rats. Pharmacological implications for use of sulfoxide analogues 3 and 6 are discussed as prodrugs to potent selective COX-2 inhibitors 1 and 4.

Original languageEnglish
Pages (from-to)1757-1760
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number7
DOIs
StatePublished - Apr 2004

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