A preliminary X-ray study of murine Tnfaip8/Oxi-α

Daeun Lee, Mi Sun Kim, Jimin Park, Gil Ja Jhon, Jin H. Son, Dong Hae Shin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P21212, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 Å. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.

Original languageEnglish
Pages (from-to)4523-4530
Number of pages8
JournalInternational Journal of Molecular Sciences
Issue number3
StatePublished - 14 Mar 2014


  • C165S mutant
  • Oxi-α
  • Oxidative stress
  • Parkinson's disease
  • X-ray crystallography


Dive into the research topics of 'A preliminary X-ray study of murine Tnfaip8/Oxi-α'. Together they form a unique fingerprint.

Cite this