A potential cytotoxic principle of Zingiber cassumunar

Ah Reum Han; Eun Jin Lee; Hye Young Min; Hyang Rim Kim; Sang Kook Lee; Eun Kyoung Seo

A potential cytotoxic principle of Zingiber cassumunar

Ah Reum Han, Eun Jin Lee, Hye Young Min, Hyang Rim Kim, Sang Kook Lee, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC₅₀ 18.80 μg/ml).

Original language	English
Pages (from-to)	109-111
Number of pages	3
Journal	Natural Product Sciences
Volume	9
Issue number	2
State	Published - Jun 2003

Keywords

(E)-4-(3′,4′- dimethoxyphenyl)but-3-en-1-ol
(E)-4-(3′,4′-dimethoxyphenyl) but-3-en-1-yl acetate
Curcumin
Cytotoxicity
Rhizome
Zingiber cassumunar
Zingiberaceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "A potential cytotoxic principle of Zingiber cassumunar",

abstract = "A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC50 18.80 μg/ml).",

keywords = "(E)-4-(3′,4′- dimethoxyphenyl)but-3-en-1-ol, (E)-4-(3′,4′-dimethoxyphenyl) but-3-en-1-yl acetate, Curcumin, Cytotoxicity, Rhizome, Zingiber cassumunar, Zingiberaceae",

author = "Han, {Ah Reum} and Lee, {Eun Jin} and Min, {Hye Young} and Kim, {Hyang Rim} and {Kook Lee}, Sang and Seo, {Eun Kyoung}",

year = "2003",

month = jun,

language = "English",

volume = "9",

pages = "109--111",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "2",

}

TY - JOUR

T1 - A potential cytotoxic principle of Zingiber cassumunar

AU - Han, Ah Reum

AU - Lee, Eun Jin

AU - Min, Hye Young

AU - Kim, Hyang Rim

AU - Kook Lee, Sang

AU - Seo, Eun Kyoung

PY - 2003/6

Y1 - 2003/6

N2 - A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC50 18.80 μg/ml).

AB - A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC50 18.80 μg/ml).

KW - (E)-4-(3′,4′- dimethoxyphenyl)but-3-en-1-ol

KW - (E)-4-(3′,4′-dimethoxyphenyl) but-3-en-1-yl acetate

KW - Curcumin

KW - Cytotoxicity

KW - Rhizome

KW - Zingiber cassumunar

KW - Zingiberaceae

UR - http://www.scopus.com/inward/record.url?scp=0037826161&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0037826161

SN - 1226-3907

VL - 9

SP - 109

EP - 111

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 2

ER -

A potential cytotoxic principle of Zingiber cassumunar

Abstract

Keywords

UN SDGs

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