A potential cytotoxic principle of Zingiber cassumunar

Ah Reum Han, Eun Jin Lee, Hye Young Min, Hyang Rim Kim, Sang Kook Lee, Eun Kyoung Seo

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9 Scopus citations


A bioassay-guided fractionation of the active chloroform extracts of the rhizomes of Zingiber cassumunar Roxb. led to the isolation of a potential cytotoxic principle, curcumin (1), along with two inactive compounds, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2) and (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-yl acetate (3). Curcumin (1) showed a significant cytotoxicity against several human cancer cell lines (Col2; 2.30, A549; 12.30, SNU638; IC50 18.80 μg/ml).

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalNatural Product Sciences
Issue number2
StatePublished - Jun 2003


  • (E)-4-(3′,4′- dimethoxyphenyl)but-3-en-1-ol
  • (E)-4-(3′,4′-dimethoxyphenyl) but-3-en-1-yl acetate
  • Curcumin
  • Cytotoxicity
  • Rhizome
  • Zingiber cassumunar
  • Zingiberaceae


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