A portable and multiplexed bioelectronic sensor using human olfactory and taste receptors

Manki Son; Daesan Kim; Hwi Jin Ko; Seunghun Hong; Tai Hyun Park

doi:10.1016/j.bios.2016.09.040

A portable and multiplexed bioelectronic sensor using human olfactory and taste receptors

Manki Son, Daesan Kim, Hwi Jin Ko, Seunghun Hong, Tai Hyun Park

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

A multiplexed bioelectronic sensor was developed for the purpose of rapid, on-site, and simultaneous detection of various target molecules. Olfactory and taste receptors were produced in Escherichia coli, and the reconstituted receptors were immobilized onto a multi-channel type carbon nanotube field-effect transistor. This device mimicked the human olfactory/taste system and simultaneously measured the conductance changes with high sensitivity and selectivity following treatment with various odor and taste molecules commonly known to be indicators of food contamination. Various pattern recognition of odorants and tastants was available with a customized platform for the simultaneous measurement of electrical signals. The simple portable bioelectronic device was suitable for efficient monitoring of food freshness and is expected to be used as a rapid on-site sensing platform with various applications.

Original language	English
Pages (from-to)	901-907
Number of pages	7
Journal	Biosensors and Bioelectronics
Volume	87
DOIs	https://doi.org/10.1016/j.bios.2016.09.040
State	Published - 15 Jan 2017

Bibliographical note

Funding Information:
The authors thank Dr. Kyung Hyun Park for his support with the portable monitoring system from the THz Photonics Creative Research Center of the Electronics and Telecommunications Research Institute. This research was supported by the Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning ( 2014039771 ), the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) ( 2014053108 ) and the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT & Future Planning as a Global Frontier Project ( CISS-2011-0031870 ). SH acknowledges the support from the NRF grants (H-GUARD 2013M3A6B2078961 , 2014M3A7B4051591 ).

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

Bioelectronic sensor
Carbon nanotube
Field-effect transistor
Human olfactory receptor
Human taste receptor

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abstract = "A multiplexed bioelectronic sensor was developed for the purpose of rapid, on-site, and simultaneous detection of various target molecules. Olfactory and taste receptors were produced in Escherichia coli, and the reconstituted receptors were immobilized onto a multi-channel type carbon nanotube field-effect transistor. This device mimicked the human olfactory/taste system and simultaneously measured the conductance changes with high sensitivity and selectivity following treatment with various odor and taste molecules commonly known to be indicators of food contamination. Various pattern recognition of odorants and tastants was available with a customized platform for the simultaneous measurement of electrical signals. The simple portable bioelectronic device was suitable for efficient monitoring of food freshness and is expected to be used as a rapid on-site sensing platform with various applications.",

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author = "Manki Son and Daesan Kim and Ko, {Hwi Jin} and Seunghun Hong and Park, {Tai Hyun}",

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A portable and multiplexed bioelectronic sensor using human olfactory and taste receptors

Abstract

Bibliographical note

Keywords

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