A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

Yeni Lim; Sena Lee; Ji Yeon Kim; Jae Ho Shin; Oran Kwon

doi:10.1016/j.jff.2016.04.012

A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

Yeni Lim
, Sena Lee
, Ji Yeon Kim
, Jae Ho Shin
, Oran Kwon

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.

Original language	English
Pages (from-to)	231-243
Number of pages	13
Journal	Journal of Functional Foods
Volume	24
DOIs	https://doi.org/10.1016/j.jff.2016.04.012
State	Published - 1 Jun 2016

Bibliographical note

Funding Information:
We thank Dr. Cheol-Ho Pan at Korea Institute of Science and Technology for HPLC-MS analysis. This project was supported by the Ministry of Trade, Industry and Energy/KIAT (Establishment of Infra Structure for Anti-Aging Industry Support, N0000697 ) and the Ministry of Science, ICT and Future Planning ( NRF 2013M3A9C4078153 ). The funding source was not involved in the collection, analysis, and interpretation of the data; the writing of this paper; or the decision to submit this manuscript for publication.

Publisher Copyright:
© 2016 Elsevier Ltd.

Keywords

Atherothrombotic profile
Combination supplement of Phellinus baumii and Salvia miltiorrhiza Bunge
Cyclooxygenase
Endothelial nitric oxide synthase
Platelet activation model

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10.1016/j.jff.2016.04.012

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@article{e73f5f564c824f899ef7b81ceafe3407,

title = "A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo",

abstract = "Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.",

keywords = "Atherothrombotic profile, Combination supplement of Phellinus baumii and Salvia miltiorrhiza Bunge, Cyclooxygenase, Endothelial nitric oxide synthase, Platelet activation model",

author = "Yeni Lim and Sena Lee and Kim, \{Ji Yeon\} and Shin, \{Jae Ho\} and Oran Kwon",

note = "Funding Information: We thank Dr. Cheol-Ho Pan at Korea Institute of Science and Technology for HPLC-MS analysis. This project was supported by the Ministry of Trade, Industry and Energy/KIAT (Establishment of Infra Structure for Anti-Aging Industry Support, N0000697 ) and the Ministry of Science, ICT and Future Planning ( NRF 2013M3A9C4078153 ). The funding source was not involved in the collection, analysis, and interpretation of the data; the writing of this paper; or the decision to submit this manuscript for publication. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.jff.2016.04.012",

language = "English",

volume = "24",

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journal = "Journal of Functional Foods",

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A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo. / Lim, Yeni; Lee, Sena; Kim, Ji Yeon et al.
In: Journal of Functional Foods, Vol. 24, 01.06.2016, p. 231-243.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

AU - Lim, Yeni

AU - Lee, Sena

AU - Kim, Ji Yeon

AU - Shin, Jae Ho

AU - Kwon, Oran

N1 - Funding Information: We thank Dr. Cheol-Ho Pan at Korea Institute of Science and Technology for HPLC-MS analysis. This project was supported by the Ministry of Trade, Industry and Energy/KIAT (Establishment of Infra Structure for Anti-Aging Industry Support, N0000697 ) and the Ministry of Science, ICT and Future Planning ( NRF 2013M3A9C4078153 ). The funding source was not involved in the collection, analysis, and interpretation of the data; the writing of this paper; or the decision to submit this manuscript for publication. Publisher Copyright: © 2016 Elsevier Ltd.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.

AB - Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.

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KW - Combination supplement of Phellinus baumii and Salvia miltiorrhiza Bunge

KW - Cyclooxygenase

KW - Endothelial nitric oxide synthase

KW - Platelet activation model

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DO - 10.1016/j.jff.2016.04.012

M3 - Article

AN - SCOPUS:84964325962

SN - 1756-4646

VL - 24

SP - 231

EP - 243

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

Abstract

Bibliographical note

Keywords

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