A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo

Yeni Lim, Sena Lee, Ji Yeon Kim, Jae Ho Shin, Oran Kwon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.

Original languageEnglish
Pages (from-to)231-243
Number of pages13
JournalJournal of Functional Foods
Volume24
DOIs
StatePublished - 1 Jun 2016

Bibliographical note

Funding Information:
We thank Dr. Cheol-Ho Pan at Korea Institute of Science and Technology for HPLC-MS analysis. This project was supported by the Ministry of Trade, Industry and Energy/KIAT (Establishment of Infra Structure for Anti-Aging Industry Support, N0000697 ) and the Ministry of Science, ICT and Future Planning ( NRF 2013M3A9C4078153 ). The funding source was not involved in the collection, analysis, and interpretation of the data; the writing of this paper; or the decision to submit this manuscript for publication.

Publisher Copyright:
© 2016 Elsevier Ltd.

Keywords

  • Atherothrombotic profile
  • Combination supplement of Phellinus baumii and Salvia miltiorrhiza Bunge
  • Cyclooxygenase
  • Endothelial nitric oxide synthase
  • Platelet activation model

Fingerprint

Dive into the research topics of 'A Phellinus baumii-based supplement containing Salvia miltiorrhiza Bunge improves atherothrombotic profiles through endothelial nitric oxide synthase and cyclooxygenase pathways in vitro and in vivo'. Together they form a unique fingerprint.

Cite this