Abstract
Given the high prevalence of atherothrombotic disease and increasing attention to functional foods, we tested the hypothesis that a combination supplement (PS) containing Phellinus baumii (PB) and Salvia miltiorrhiza Bunge (SM) may improve the atherothrombotic profile in rats. The PS (Experiment 1) or PB/SM (Experiment 2) supplement was administered orally once daily for 7 days prior to inducing platelet activation at the last day. Orally administered PS showed an additive and positive effect on nitric oxide (NO) availability, adhesion molecule/pro-inflammatory cytokine release, and thrombosis compared to controls. This effect was attributed more to PB than to SM for cyclooxygenase (COX)-1 and to SM for COX-2. In vitro data revealed that tanshinone IIA derived from SM remarkably suppressed COX-2, and protocatechuic acid derived from PB caused a small increase in NO production. The data suggest the potential use of PS to ameliorate endothelial and vascular dysfunction induced by unintended platelet activation.
Original language | English |
---|---|
Pages (from-to) | 231-243 |
Number of pages | 13 |
Journal | Journal of Functional Foods |
Volume | 24 |
DOIs | |
State | Published - 1 Jun 2016 |
Bibliographical note
Funding Information:We thank Dr. Cheol-Ho Pan at Korea Institute of Science and Technology for HPLC-MS analysis. This project was supported by the Ministry of Trade, Industry and Energy/KIAT (Establishment of Infra Structure for Anti-Aging Industry Support, N0000697 ) and the Ministry of Science, ICT and Future Planning ( NRF 2013M3A9C4078153 ). The funding source was not involved in the collection, analysis, and interpretation of the data; the writing of this paper; or the decision to submit this manuscript for publication.
Publisher Copyright:
© 2016 Elsevier Ltd.
Keywords
- Atherothrombotic profile
- Combination supplement of Phellinus baumii and Salvia miltiorrhiza Bunge
- Cyclooxygenase
- Endothelial nitric oxide synthase
- Platelet activation model