A phase I study of cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II)in patients with advanced malignancies

Medicine and Dentistry

• Pharmacokinetics 100%
• Liver Toxicity 100%
• Platinum 100%
• Plasma Half Life 100%
• 1,3 Dioxolane 100%
• Disease 50%
• Urinary Excretion 50%
• Proteinuria 50%
• Mucositis 50%
• Intravenous Drug Administration 50%
• Vomiting 50%
• Antiemetic 50%
• Nausea 50%
• Thrombocytopenia 50%
• Uremia 50%
• Bone Marrow Suppression 50%
• Leukopenia 50%
• Platinum Derivative 50%
• 1,3 Dioxolane Derivative 50%
• Nephrotoxicity 50%
• Neurotoxicity 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Hepatotoxicity 100%
• Platinum 100%
• 1,3 Dioxolane 100%
• Maximum Tolerated Dose 100%
• Pharmacokinetics 100%
• Nephrotoxicity 50%
• Neurotoxicity 50%
• Renal Excretion 50%
• Mucosa Inflammation 50%
• Antiemetic Agent 50%
• Nausea 50%
• Vomiting 50%
• Platinum Derivative 50%
• 1,3 Dioxolane Derivative 50%
• Disease 50%
• Proteinuria 50%
• Thrombocytopenia 50%
• Uremia 50%
• Leukopenia 50%
• Bone Marrow Suppression 50%