A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice

Medicine & Life Sciences

• TM5441 100%
• Plasminogen Activator Inhibitor 1 49%
• High Fat Diet 44%
• Adipocytes 41%
• Obesity 30%
• Wounds and Injuries 21%
• Insulin Resistance 13%
• Fats 8%
• Organelle Biogenesis 6%
• Physiological Stress 6%
• Nitric Oxide Synthase Type II 5%
• Sucrose 5%
• Inbred C57BL Mouse 5%
• Metabolic Syndrome 5%
• Weight Gain 5%
• Chronic Disease 4%
• Body Weight 3%
• Down-Regulation 3%
• Macrophages 3%
• Phosphorylation 3%
• Diet 3%
• Hemorrhage 3%
• Cytokines 3%
• Inflammation 3%
• Genes 2%
• Therapeutics 1%