A novel organogermanium protected atopic dermatitis induced by oxazolone

Doo Hyeon Lim, Minghua Li, Jung A. Seo, Kyung Min Lim, Seung Wook Ham

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-γ inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.

Original languageEnglish
Pages (from-to)4032-4034
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number14
DOIs
StatePublished - 15 Jul 2010

Keywords

  • Anti-AD activities
  • Atopic dermatitis (AD)
  • Murine model
  • Organogermanium

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