A novel organogermanium protected atopic dermatitis induced by oxazolone

Doo Hyeon Lim; Minghua Li; Jung A. Seo; Kyung Min Lim; Seung Wook Ham

doi:10.1016/j.bmcl.2010.05.097

A novel organogermanium protected atopic dermatitis induced by oxazolone

Doo Hyeon Lim, Minghua Li, Jung A. Seo, Kyung Min Lim, Seung Wook Ham

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-γ inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.

Original language	English
Pages (from-to)	4032-4034
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2010.05.097
State	Published - 15 Jul 2010

Keywords

Anti-AD activities
Atopic dermatitis (AD)
Murine model
Organogermanium

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10.1016/j.bmcl.2010.05.097

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title = "A novel organogermanium protected atopic dermatitis induced by oxazolone",

abstract = "Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-γ inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.",

keywords = "Anti-AD activities, Atopic dermatitis (AD), Murine model, Organogermanium",

author = "Lim, {Doo Hyeon} and Minghua Li and Seo, {Jung A.} and Lim, {Kyung Min} and Ham, {Seung Wook}",

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AU - Lim, Doo Hyeon

AU - Li, Minghua

AU - Seo, Jung A.

AU - Lim, Kyung Min

AU - Ham, Seung Wook

PY - 2010/7/15

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AB - Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-γ inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.

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KW - Murine model

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A novel organogermanium protected atopic dermatitis induced by oxazolone

Abstract

Keywords

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