A novel method for the synthesis of 1,2-benzisoxazoline-3-one and its application to hypochlorite recognition

Yutao Yang, Fangjun Huo, Caixia Yin, Ming Xu, Ying Hu, Jianbin Chao, Yongbin Zhang, Timothy E. Glass, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The reaction of salicylhydroxamic acid with hypochlorite produces 1,2-benzisoxazoline-3-one, a heterocycle that contains a fluorophore. As a result, this reaction was used as the basis for a new, selective and sensitive fluorescence system for the recognition of hypochlorite. The effectiveness of the method was demonstrated by its use to detect hypochlorite in a disinfectant solution as well as to image hypochlorite in cells.

Original languageEnglish
Pages (from-to)5101-5104
Number of pages4
JournalJournal of Materials Chemistry B
Volume4
Issue number30
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
The work was supported by the National Natural Science Foundation of China (No. 21472118), the Taiyuan Technology star special (No. 12024703), the Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi (2013802), the Talents Support Program of Shanxi Province (2014401), the Shanxi Province Outstanding Youth Fund (No. 2014021002) and the National Science Foundation (CHE-1507119). This research was also supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814).

Publisher Copyright:
© The Royal Society of Chemistry 2016.

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