@inproceedings{d2b798641fc44e569709cf7e5937e217,
title = "A novel droplet-based three dimensional co-culture array system for high-throughput assay of tumor angiogenesis",
abstract = "We proposed a novel 3D-2D co-culture droplet array system to analyze tumor angiogenesis in a high throughput manner. A two-layer PDMS chip with 6 ×9 paired-well array was fabricated for cell co-culture. Each paired-well was composed of a TC well for Matrigel-coated tumor cells aggregated into 3D spheroids within droplet with a hypoxia-center similar to real tumor tissues, and an EC well for HUVECs cultured in 2D within droplet. Co-cultured tumor cells were able to interact with HUVECs and induce angiogenesis. Controlled by an automated DropLab system, multiple paired samples could be analyzed simultaneously in high-throughput through the droplet array.",
keywords = "Co-culture, High-throughput, Microfluidic droplet array, Tumor angiogenesis",
author = "Xiaohui Du and Wanming Li and Guansheng Du and Hansang Cho and Qun Fang and Lee, {Luke P.} and Jin Fang",
note = "Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",
year = "2015",
language = "English",
series = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "565--567",
booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}