@article{fd6cd256df654fffab3870e9a265c8c1,
title = "A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2",
abstract = "Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein-2 (CCSP-2) is a promising blood marker for CRC. An electric-field effect colorectal sensor (E-FECS), an ion-sensitive field-effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP-2 directly from patient blood samples. The sensing performance of the E-FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP-2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP-2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E-FECS system successfully detects CCSP-2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP-2 has potential for use as a blood-based biomarker for CRC.",
keywords = "colorectal adenomas, colorectal cancer, colorectal cancer screening, electric-field effect colorectal sensor, tumor markers",
author = "Minhong Jeun and Lee, {Hyo Jeong} and Sungwook Park and Do, {Eun ju} and Jaewon Choi and Sung, {You Na} and Hong, {Seung Mo} and Kim, {Sang Yeob} and Kim, {Dong Hee} and Kang, {Ja Young} and Son, {Hye Nam} and Jinmyoung Joo and Song, {Eun Mi} and Hwang, {Sung Wook} and Park, {Sang Hyoung} and Yang, {Dong Hoon} and Ye, {Byong Duk} and Byeon, {Jeong Sik} and Jaewon Choe and Yang, {Suk Kyun} and Helen Moinova and Markowitz, {Sanford D.} and Lee, {Kwan Hyi} and Myung, {Seung Jae}",
note = "Funding Information: M.J, H.J.L, and S.P. contributed equally to this work. The authors thank Dr. Joon Seo Lim from the Scientific Publications Team at Asan Medical Center for his editorial assistance in preparing this manuscript. This research was supported by grants of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI15C3078 and No. HI14C1090), the Ministry of Trade, Industry & Energy (MOTIE, Korea) under Industrial Technology Innovation Program (No. 10063408), the grant from Asan Institute for Life Sciences (No. 2018-559), and the Bio & Medical Technology Development Program of the NRF funded by the Korean government MSIP (2015M3A9E2029265). Publisher Copyright: {\textcopyright} 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jun,
day = "5",
doi = "10.1002/advs.201802115",
language = "English",
volume = "6",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-VCH Verlag",
number = "11",
}