A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2

Minhong Jeun, Hyo Jeong Lee, Sungwook Park, Eun ju Do, Jaewon Choi, You Na Sung, Seung Mo Hong, Sang Yeob Kim, Dong Hee Kim, Ja Young Kang, Hye Nam Son, Jinmyoung Joo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong Hoon Yang, Byong Duk Ye, Jeong Sik Byeon, Jaewon Choe, Suk Kyun YangHelen Moinova, Sanford D. Markowitz, Kwan Hyi Lee, Seung Jae Myung

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein-2 (CCSP-2) is a promising blood marker for CRC. An electric-field effect colorectal sensor (E-FECS), an ion-sensitive field-effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP-2 directly from patient blood samples. The sensing performance of the E-FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP-2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP-2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E-FECS system successfully detects CCSP-2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP-2 has potential for use as a blood-based biomarker for CRC.

Original languageEnglish
Article number1802115
JournalAdvanced Science
Volume6
Issue number11
DOIs
StatePublished - 5 Jun 2019

Keywords

  • colorectal adenomas
  • colorectal cancer
  • colorectal cancer screening
  • electric-field effect colorectal sensor
  • tumor markers

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