A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata

Ah Reum Han, Jong Bin Kim, Jun Lee, Joo Won Nam, Ik Soo Lee, Chang Koo Shim, Kyung Tae Lee, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A new flavanone glycoside, (2R)-5-hydroxy-4′-methoxyflavanone-7-O- {β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells.

Original languageEnglish
Pages (from-to)1270-1273
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Interleukin-6
  • New flavanone
  • Poncirus trifoliata
  • Prostaglandin E

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