A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

Ah Reum Han; Hye Young Min; Tri Windono; Cwang Ho Jeohn; Dae Sik Jang; Sang Kook Lee; Eun Kyoung Seo

doi:10.1055/s-2004-832656

A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

Ah Reum Han
, Hye Young Min
, Tri Windono
, Cwang Ho Jeohn
, Dae Sik Jang
, Sang Kook Lee
, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.

Original language	English
Pages (from-to)	1095-1097
Number of pages	3
Journal	Planta Medica
Volume	70
Issue number	11
DOIs	https://doi.org/10.1055/s-2004-832656
State	Published - Nov 2004

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SDG 3 Good Health and Well-being

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10.1055/s-2004-832656

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@article{27c476e607824dd8bddd5f4678ff3381,

title = "A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar",

abstract = "A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.",

author = "Han, \{Ah Reum\} and Min, \{Hye Young\} and Tri Windono and Jeohn, \{Cwang Ho\} and Jang, \{Dae Sik\} and Lee, \{Sang Kook\} and Seo, \{Eun Kyoung\}",

year = "2004",

month = nov,

doi = "10.1055/s-2004-832656",

language = "English",

volume = "70",

pages = "1095--1097",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

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}

TY - JOUR

T1 - A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

AU - Han, Ah Reum

AU - Min, Hye Young

AU - Windono, Tri

AU - Jeohn, Cwang Ho

AU - Jang, Dae Sik

AU - Lee, Sang Kook

AU - Seo, Eun Kyoung

PY - 2004/11

Y1 - 2004/11

N2 - A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.

AB - A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.

UR - https://www.scopus.com/pages/publications/9744249443

U2 - 10.1055/s-2004-832656

DO - 10.1055/s-2004-832656

M3 - Article

C2 - 15549671

AN - SCOPUS:9744249443

SN - 0032-0943

VL - 70

SP - 1095

EP - 1097

JO - Planta Medica

JF - Planta Medica

IS - 11

ER -

A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

Abstract

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