A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar

Ah Reum Han, Hye Young Min, Tri Windono, Cwang Ho Jeohn, Dae Sik Jang, Sang Kook Lee, Eun Kyoung Seo

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34 Scopus citations

Abstract

A new phenylbutenoid dimer, (±)-trans-3-(4-hydroxy-3-methoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (±)-trans-3-(3, 4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3- diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including ID and 2D NMR experiments.

Original languageEnglish
Pages (from-to)1095-1097
Number of pages3
JournalPlanta Medica
Volume70
Issue number11
DOIs
StatePublished - Nov 2004

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